Embryo-fetal safety evaluation of ondansetron in rats

被引：1

作者：

Reis, Ana Carolina Casali ^{[1
]}

Jorge, Barbara Campos ^{[1
]}

Moreira, Suyane da Silva ^{[1
]}

Stein, Julia ^{[1
]}

Perdao, Carolina Barizan ^{[1
]}

Manoel, Beatriz de Matos ^{[2
]}

Arena, Arielle Cristina ^{[1
,3
,4
]}

机构：

[1] Univ Estadual Paulista UNESP, Inst Biosci Botucatu, Dept Struct & Funct Biol, Botucatu, SP, Brazil

[2] Fed Univ Grande Dourados, Coll Hlth Sci, Dourados, MS, Brazil

[3] Univ Estadual Paulista Botucatu UNESP, Inst Biosci Botucatu, Ctr Toxicol Assistance CEATOX, Botucatu, SP, Brazil

[4] Sao Paulo State Univ UNESP, Inst Biosci Botucatu, Dept Struct & Funct Biol, S-N,Caixa Postal 510, BR-18618970 Botucatu, SP, Brazil

来源：

BIRTH DEFECTS RESEARCH | 2023年 / 115卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

kidney; nausea and vomiting; organogenesis; rats; safety; teratogenicity; PREGNANCY; NAUSEA; MALFORMATIONS; TERATOGENS; EXPOSURE;

D O I：

10.1002/bdr2.2154

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Ondansetron is a 5HT3 receptor antagonist, used to mitigate the effects of nausea and vomiting after chemotherapy or surgery. Since nausea and vomiting are common experiences during the first trimester of pregnancy, this antiemetic has been the main drug used during this period.Methods: To evaluate the effects of ondansetron on the embryo-fetal development, which are still very contradictory, pregnant rats were exposed to therapeutic doses of ondansetron (1.7 or 2.5 mg/kg) daily, from gestational day (GD) 6 to 15.Results: No clinical signs of toxicity were observed in dams during the treatment. Although the hematobiochemical parameters were similar among the groups, histological changes, as well as a reduction in the weight of kidney were found in the treated dams. After fetal examination, no visceral and skeletal abnormalities were observed in treated fetuses.Conclusion: In conclusion, therapeutic doses of ondansetron have low terato-genic potential in rats. These data provide important information about the drug safety during pregnancy.

引用

页码：605 / 613

页数：9

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