Organocatalytic regio- and enantioselective vinylogous aza-Morita-Baylis-Hillman reaction

被引：2
|
作者：
Gondo, Naruhiro [1 ]
Fujimura, Koki [1 ]
Hyakutake, Ryuichi [1 ]
Ueda, Yoshihiro [1 ]
Kawabata, Takeo [1 ,2 ]
机构：
[1] Kyoto Univ, Inst Chem Res, Uji, Kyoto 6110011, Japan
[2] Int Univ Hlth & Welf, Dept Pharmaceut Sci, 137-1 Enokizu, Okawa, Fukuoka 831501, Japan
来源：
TETRAHEDRON LETTERS | 2023年 / 115卷
关键词：
Asymmetric organocatalysis; Aza-Morita-Baylis-Hillman reaction; Chiral amine; Regioselectivity; 7-Selectivity; SITE-SELECTIVE ACYLATION; CATALYSTS; ACID; FUNCTIONALIZATION; ELLAGITANNINS; ACTIVATION; MECHANISM; STRATEGY; IMINES;
D O I：
10.1016/j.tetlet.2022.154306
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Asymmetric regioselective vinylogous aza-Morita-Baylis-Hillman reactions by organocatalysis were developed. The reactions of 3-vinylcyclopentenone with various aldimines in the presence of chiral pyrrolidinopyridine catalysts gave the 7-adducts in high regioselectivity and moderate enantioselectivity.(c) 2022 Elsevier Ltd. All rights reserved.
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页数：5
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