Croton stipulaceus Kunth, a native Mexican medicinal plant with antioxidant and anti-inflammatory activities

被引：0

作者：

Moreno-Quiros, Claudia, V

Garcia-Escalante, Victor ^{[1
,2
]}

Sanchez-Medina, Alberto

Ramos-Morales, Fernando Rafael

Reyes-Tellez, Araceli ^{[1
]}

Mendez-Bolaina, Enrique ^{[3
]}

V. Garcia-Rodriguez, Rosa ^{[1
]}

机构：

[1] Univ Veracruzana, Inst Quim Aplicada, Xalapa, Veracruz, Mexico

[2] Univ Veracruzana, Fac Quim Farmaceut Biol, Xalapa, Veracruz, Mexico

[3] Univ Veracruzana, Fac Ciencias Quim, Orizaba, Veracruz, Mexico

来源：

BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2024年 / 23卷 / 04期

关键词：

Croton stipulaceus Kunth; Antioxidant; Anti-inflammatory; Medicinal plant; Myeloperoxidase; CARRAGEENAN-INDUCED EDEMA; SKIN INFLAMMATION; DRAGONS BLOOD; DPPH; EXTRACT; ASSAY; FRAP;

D O I：

10.37360/blacpma.24.23.4.35

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Leaves of Croton stipulaceus were extracted (EHex, ECHCl3 and EEtOH extracts) to assess their antioxidant potential, anti-inflammatory activity in murine models and acute toxicity. EEtOH showed the highest effect in DPPH (37.80% inhibition), FRAP (1065.00 +/- 55.30 mu mol Fe2+) and total polyphenols (231.24 +/- 9.05 meq AG/gM). EHex was the most active, similar to 50% inhibition of TPA-induced ear edema; while EEtOH (dose of 2 mg/ear) showed the highest inhibition in the chronic model (97% inhibition), and inhibited MPO activity (48%). In carrageenan-induced edema, ECHCl3 (dose 500 mg/kg) was the most active. None of the extracts showed acute toxicity (LD50) at 2 g/kg (p.o.). This work is the first report that supports the traditional use of C. stipulaceus as an anti-inflammatory.

引用

页码：523 / 533

页数：11

共 47 条

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