Role of stress granules in tumorigenesis and cancer therapy

被引：18
作者：
Li, Tiansheng [1 ,2 ,3 ,4 ]
Zeng, Zhaoyang [1 ,2 ,3 ,4 ]
Fan, Chunmei [1 ,2 ,3 ,4 ,5 ]
Xiong, Wei [1 ,2 ,3 ,4 ]
机构：
[1] Cent South Univ, NHC Key Lab Carcinogenesis, Changsha, Hunan, Peoples R China
[2] Cent South Univ, Hunan Canc Hosp, Hunan Key Lab Canc Metab, Changsha, Hunan, Peoples R China
[3] Cent South Univ, Canc Hosp, Xiangya Sch Med, Changsha, Hunan, Peoples R China
[4] Cent South Univ, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Canc Res Inst, Changsha, Hunan, Peoples R China
[5] Cent South Univ, Xiangya Sch Med, Dept Histol & Embryol, Changsha, Hunan, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2023年 / 1878卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Stress granule; Liquid-liquid phase separation; Cancer; Cancer therapy; EUKARYOTIC TRANSLATION INITIATION; SMALL-MOLECULE INHIBITION; MESSENGER-RNA; GLUTAMINE-METABOLISM; UP-REGULATION; MULTIKINASE INHIBITOR; CELL-PROLIFERATION; BINDING PROTEINS; P-BODIES; EXPRESSION;
D O I：
10.1016/j.bbcan.2023.189006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Stress granules (SGs) are membrane-less organelles that cell forms via liquid-liquid phase separation (LLPS) under stress conditions such as oxidative stress, ER stress, heat shock and hypoxia. SG assembly is a stress-responsive mechanism by regulating gene expression and cellular signaling pathways. Cancer cells face various stress conditions in tumor microenvironment during tumorigenesis, while SGs contribute to hallmarks of cancer including proliferation, invasion, migration, avoiding apoptosis, metabolism reprogramming and immune evasion. Here, we review the connection between SGs and cancer development, the limitation of SGs on current cancer therapy and promising cancer therapeutic strategies targeting SGs in the future.
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页数：15
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共 201 条
  • [1] Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation
    Adjibade, Pauline
    Simoneau, Bryan
    Ledoux, Nassim
    Gauthier, William-Naud
    Nkurunziza, Melisse
    Khandjian, Edouard W.
    Mazroui, Rachid
    [J]. PLOS ONE, 2020, 15 (05):
  • [2] Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells
    Adjibade, Pauline
    St-Sauveur, Valerie Grenier
    Huberdeau, Miguel Quevillon
    Fournier, Marie-Josee
    Savard, Andreanne
    Coudert, Laetitia
    Khandjian, Edouard W.
    Mazroui, Rachid
    [J]. ONCOTARGET, 2015, 6 (41) : 43927 - 43943
  • [3] Radiotherapy for Cancer: Present and Future
    Allen, Christine
    Her, Sohyoung
    Jaffray, David A.
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2017, 109 : 1 - 2
  • [4] Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2+ Breast Cancer
    Alwarawrah, Yazan
    Hughes, Philip
    Loiselle, David
    Carlson, David A.
    Darr, David B.
    Jordan, Jamie L.
    Xiong, Jessie
    Hunter, Lucas M.
    Dubois, Laura G.
    Thompson, J. Will
    Kulkarni, Manjusha M.
    Ratcliff, Annette N.
    Kwiek, Jesse J.
    Haystead, Timothy A. J.
    [J]. CELL CHEMICAL BIOLOGY, 2016, 23 (06): : 678 - 688
  • [5] Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability
    Amen, Triana
    Kaganovich, Daniel
    [J]. CELL REPORTS, 2021, 35 (11):
  • [6] Fasnall Induces Atypically Transient Stress Granules Independently of FASN Inhibition
    Amen, Triana
    Kaganovich, Daniel
    [J]. ISCIENCE, 2020, 23 (10)
  • [7] Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response
    Anand, Aditya A.
    Walter, Peter
    [J]. FEBS JOURNAL, 2020, 287 (02) : 239 - 245
  • [8] The Chemotherapeutic Drug 5-Fluorouracil Promotes PKR-Mediated Apoptosis in a p53-Independent Manner in Colon and Breast Cancer Cells
    Angel Garcia, Maria
    Carrasco, Esther
    Aguilera, Margarita
    Alvarez, Pablo
    Rivas, Carmen
    Maria Campos, Joaquin
    Carlos Prados, Jose
    Angel Calleja, Miguel
    Esteban, Mariano
    Antonio Marchal, Juan
    Aranega, Antonia
    [J]. PLOS ONE, 2011, 6 (08):
  • [9] Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways
    Arimoto, Kyoko
    Fukuda, Hiroyuki
    Imajoh-Ohmi, Shinobu
    Saito, Haruo
    Takekawa, Mutsuhiro
    [J]. NATURE CELL BIOLOGY, 2008, 10 (11) : 1324 - U167
  • [10] Raloxifene prevents stress granule dissolution, impairs translational control and promotes cell death during hypoxia in glioblastoma cells
    Attwood, Kathleen M.
    Robichaud, Aaron
    Westhaver, Lauren P.
    Castle, Elizabeth L.
    Brandman, David M.
    Balgi, Aruna D.
    Roberge, Michel
    Colp, Patricia
    Croul, Sidney
    Kim, Inhwa
    McCormick, Craig
    Corcoran, Jennifer A.
    Weeks, Adrienne
    [J]. CELL DEATH & DISEASE, 2020, 11 (11)
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