Three novel dalbergiphenol hybrids from the heartwood of Dalbergia cochinchinensis

被引：0
|
作者：
Ren, Jia-Hui [1 ]
Liu, Yang [2 ]
Shen, Chen-Xiao [3 ]
Zheng, Qi-Wan [1 ]
Meng, Xiao-Wei [1 ]
Li, Jia-Rong [1 ]
Chen, Lan-Ying [4 ]
Liu, Rong-Hua [1 ]
机构：
[1] Jiangxi Univ Chinese Med, Sch Pharm, Nanchang 330004, Peoples R China
[2] Fudan Univ, Sch Pharm, Dept Nat Med, 826 Zhangheng Rd,Pudong New Area, Shanghai 201203, Peoples R China
[3] Univ Macau, Inst Chinese Med Sci, Macao Ctr Res & Dev Chinese Med, Macau 999078, Peoples R China
[4] Jiangxi Univ Chinese Med, Natl Pharmaceut Engn Ctr Solid Preparat Chinese He, Nanchang 330006, Peoples R China
来源：
FITOTERAPIA | 2023年 / 170卷
关键词：
Dalbergia cochinchinensis; Leguminosae; Cochindalbergiphenols A-C; H9c2; Hypoxia/reoxygenation; LATIFOLIN; CONSTITUENTS;
D O I：
10.1016/j.fitote.2023.105663
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel discovery of two hybrid benzodioxepin-dalbergiphenol epimers, named cochindalbergiphenols A-B (1-2), and a benzofuran-dalbergiphenol hybrid, named cochindalbergiphenol C (3), were isolated and identified from the heartwood of Dalbergia cochinchinensis. The structures of all the isolated compounds were identified through NMR and HRESIMS techniques, while the absolute configurations were determined by comparing the experimental and calculated ECD spectra. Compounds 1-3 exhibited potential protective effects against hypoxia/ reoxygenation (H/R) induced injury in H9c2 cells.
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页数：6
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