Assessment of cardiovascular disease risk: a 2023 update

被引：9

作者：

Goldsborough, Earl ^{[1
]}

Tasdighi, Erfan ^{[2
]}

Blaha, Michael J. ^{[2
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[2] Johns Hopkins Univ, Ciccarone Ctr Prevent Cardiovasc Dis, Dept Med, Div Cardiol,Sch Med, Baltimore, MD USA

[3] Johns Hopkins Univ, Ciccarone Ctr Prevent Cardiovasc Dis, Div Cardiol, Dept Med,Sch Med, Baltimore, MD 21287 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 2023年 / 34卷 / 04期

基金：

美国国家卫生研究院;

关键词：

atherosclerotic cardiovascular disease; assessment; cardiovascular disease; coronary artery calcium; lipoprotein(a); CORONARY-ARTERY CALCIUM; INTIMA-MEDIA THICKNESS; HEART-DISEASE; SCIENTIFIC STATEMENT; METABOLIC SYNDROME; FAMILIAL HYPERCHOLESTEROLEMIA; LIPOPROTEIN CHOLESTEROL; APOLIPOPROTEIN-B; LDL-CHOLESTEROL; ATHEROSCLEROSIS;

D O I：

10.1097/MOL.0000000000000887

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpose of reviewThe aim of this study was to highlight the current best practice for atherosclerotic cardiovascular disease (CVD) risk evaluation, including selective use of adjunctive tools for risk stratification [e.g. coronary artery calcium (CAC) scoring] and risk enhancement [e.g. lipoprotein(a) [Lp(a)], polygenic risk scoring (PRS)].Recent findingsNew studies have evaluated the efficacy of various risk assessment tools. These studies demonstrate the role of Lp(a) as a risk-enhancing factor ready for more widespread use. CAC is the gold standard method of assessing subclinical atherosclerosis, enabling true risk stratification of patients, and informing net benefit assessment for initiating or titrating lipid-lowering therapy (LLT).Lp(a) concentration and CAC scoring, apart from the traditional risk factors, add the most value to the current CVD risk assessment approaches of all available tools, especially in terms of guiding LLT. In addition to new integrative tools such as the MESA CHD Risk Score and Coronary Age calculator, the future of risk assessment may include PRS and more advanced imaging techniques for atherosclerosis burden. Soon, polygenic risk scoring may be used to identify the age at which to begin CAC scoring, with CAC scores guiding preventive strategies.

引用

页码：162 / 173

页数：12

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