Pathogenesis of Common Ocular Diseases: Emerging Trends in Extracellular Matrix Remodeling

被引:2
|
作者
Ghorbani, Raziyeh [1 ]
Rasouli, Mehdi [1 ]
Sefat, Farshid [2 ,3 ]
Heidari Keshel, Saeed [1 ]
机构
[1] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Appl Cell Sci, Tehran, Iran
[2] Univ Bradford, Sch Engn, Dept Biomed & Elect Engn, Bradford, England
[3] Univ Bradford, Interdisciplinary Res Ctr Polymer Sci & Technol Po, Bradford, England
关键词
ECM components; ocular disorders; pathogenesis; ECM remodeling; Extracellular matrix (ECM); AGE-RELATED-CHANGES; OPTIC-NERVE; TISSUE INHIBITOR; MACULAR DEGENERATION; COLLAGEN FIBRILLOGENESIS; CONJUNCTIVAL EXPRESSION; DIFFERENTIAL EXPRESSION; MATRICELLULAR PROTEINS; TRABECULAR MESHWORK; BASEMENT-MEMBRANE;
D O I
10.1080/08820538.2023.2233601
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
The prevalence of visual impairments in human societies is worrying due to retinopathy complications of several chronic diseases such as diabetes, cardiovascular diseases, and many more that are on the rise worldwide. Since the proper function of this organ plays a pivotal role in people's quality of life, identifying factors affecting the development/exacerbation of ocular diseases is of particular interest among ophthalmology researchers. The extracellular matrix (ECM) is a reticular, three-dimensional (3D) structure that determines the shape and dimensions of tissues in the body. The ECM remodeling/hemostasis is a critical process in both physiological and pathological conditions. It consists of ECM deposition, degradation, and decrease/increase in the ECM components. However, disregulation of this process and an imbalance between the synthesis and degradation of ECM components are associated with many pathological situations, including ocular disorders. Despite the impact of ECM alterations on the development of ocular diseases, there is not much research conducted in this regard. Therefore, a better understanding in this regard, can pave the way toward discovering plausible strategies to either prevent or treat eye disorders. In this review, we will discuss the importance of ECM changes as a sentimental factor in various ocular diseases based on the research done up to now.
引用
收藏
页码:27 / 39
页数:13
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