Jiawei Sijunzi Soup Inhibits Inflammation and Oxidative Stress in the Rat Model of Diabetic Gastroparesis

被引：0
|
作者：
Zhang, Yi [1 ,3 ]
Wang, Xu [2 ]
Yang, Yiwen [1 ]
Wei, Yapin [1 ]
Sheng, Li [1 ]
Yu, Lu [1 ]
机构：
[1] Changzhou Hosp Tradit Chinese Med, Dept Endocrinol, Changzhou 213004, Jiangsu, Peoples R China
[2] Nanjing Univ Chinese Med, Dept Internal Med TCM, Nanjing 213023, Jiangsu, Peoples R China
[3] Changzhou Hosp Tradit Chinese Med, Dept Endocrinol, 25 Heping Rd South, Changzhou, Jiangsu, Peoples R China
来源：
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2023年 / 21卷 / 01期
关键词：
Diabetic gastroparesis; JWSJZD soup; Inflammation; Oxidative stress; PI3K; AKT pathway;
D O I：
10.37290/ctnr2641-452X.21:80-85
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Diabetic gastroparesis is a common complication of diabetes that may lead to poor nutrition, problems managing blood glucose, and a reduced quality of life. Jiawei Sijunzi soup has been shown to benefit patients with amyotrophic lateral sclerosis while causing no serious side effects. In this study, we investigated the possible effects of Jiawei Sijunzi soup on the progression of diabetic gastroparesis in a rat model induced by streptozotocin. The results show that Jiawei Sijunzi soup reduced inflammation and oxidative stress and improved the pathological features of gastric tissue in diabetic gastroparesis. The target of Jiawei Sijunzi soup in diabetic gastroparesis was analyzed based on network pharmacology and molecular docking techniques. The results show activation of the PI3K/AKT pathway by Jiawei Sijunzi soup in the rat model of diabetic gastroparesis.
引用
收藏
页码：80 / 85
页数：6
相关论文
共 50 条
  • [41] SIRT2 inhibits oxidative stress and inflammatory response in diabetic osteoarthritis
    Qu, Z-A
    Ma, X-J
    Huang, S-B
    Hao, X-R
    Li, D-M
    Feng, K-Y
    Wang, W-M
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2020, 24 (06) : 2855 - 2864
  • [42] The effect of N-acetylcysteine on inflammation and oxidative stress in cisplatin-induced nephrotoxicity: a rat model
    Gunturk, Inayet
    Yazici, Cevat
    Kose, Kader
    Dagli, Fatma
    Yucel, Bilal
    Yay, Arzu
    TURKISH JOURNAL OF MEDICAL SCIENCES, 2019, 49 (06) : 1789 - 1799
  • [43] Markers of Inflammation and Oxidative Stress in the Development and Progression of Renal Disease in Diabetic Patients
    Hojs, Radovan
    Ekart, Robert
    Bevc, Sebastjan
    Hojs, Nina
    NEPHRON, 2016, 133 (03) : 159 - 162
  • [44] Effect of exenatide intervention on inflammation and oxidative stress levels in patients with diabetic nephropathy
    Lu, Yanyan
    Tao, Guilu
    Zhong, Cundi
    Wang, Yuxuan
    Yin, Xiaohong
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2020, 13 (10): : 7193 - 7202
  • [45] Mepenzolate bromide promotes diabetic wound healing by modulating inflammation and oxidative stress
    Zheng, Yongjun
    Wang, Xingtong
    Ji, Shizhao
    Tian, Song
    Wu, Haibin
    Luo, Pengfei
    Fang, He
    Wang, Li
    Wu, Guosheng
    Xiao, Shichu
    Xia, Zhaofan
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2016, 8 (06): : 2738 - 2747
  • [46] Hemin attenuated oxidative stress and inflammation to improve wound healing in diabetic rats
    Kumar, Dhirendra
    Jena, Geeta Rani
    Ram, Mahendra
    Lingaraju, Madhu Cholenahalli
    Singh, Vishakha
    Prasad, Raju
    Kumawat, Sanjay
    Kant, Vinay
    Gupta, Priyanka
    Tandan, Surendra Kumar
    Kumar, Dinesh
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2019, 392 (11) : 1435 - 1445
  • [47] Hemin attenuated oxidative stress and inflammation to improve wound healing in diabetic rats
    Dhirendra Kumar
    Geeta Rani Jena
    Mahendra Ram
    Madhu Cholenahalli Lingaraju
    Vishakha Singh
    Raju Prasad
    Sanjay Kumawat
    Vinay Kant
    Priyanka Gupta
    Surendra Kumar Tandan
    Dinesh Kumar
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2019, 392 : 1435 - 1445
  • [48] Bisacurone attenuates diabetic nephropathy by ameliorating oxidative stress, inflammation and apoptosis in rats
    Yang, F.
    Zhang, Z.
    Zhang, L.
    HUMAN & EXPERIMENTAL TOXICOLOGY, 2022, 41
  • [49] Ursolic acid ameliorates oxidative stress, inflammation and fibrosis in diabetic cardiomyopathy rats
    Wang, Xu-tao
    Gong, Yan
    Zhou, Bin
    Yang, Jun-jie
    Cheng, Yin
    Zhao, Jin-guo
    Qi, Min-you
    BIOMEDICINE & PHARMACOTHERAPY, 2018, 97 : 1461 - 1467
  • [50] Combinational Approaches Targeting Neurodegeneration, Oxidative Stress, and Inflammation in the Treatment of Diabetic Retinopathy
    Chalke, Siddhi Dilip
    Kale, Pravin Popatrao
    CURRENT DRUG TARGETS, 2021, 22 (16) : 1810 - 1824
12345