Jiawei Sijunzi Soup Inhibits Inflammation and Oxidative Stress in the Rat Model of Diabetic Gastroparesis

被引：0

作者：

Zhang, Yi ^{[1
,3
]}

Wang, Xu ^{[2
]}

Yang, Yiwen ^{[1
]}

Wei, Yapin ^{[1
]}

Sheng, Li ^{[1
]}

Yu, Lu ^{[1
]}

机构：

[1] Changzhou Hosp Tradit Chinese Med, Dept Endocrinol, Changzhou 213004, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Dept Internal Med TCM, Nanjing 213023, Jiangsu, Peoples R China

[3] Changzhou Hosp Tradit Chinese Med, Dept Endocrinol, 25 Heping Rd South, Changzhou, Jiangsu, Peoples R China

来源：

CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2023年 / 21卷 / 01期

关键词：

Diabetic gastroparesis; JWSJZD soup; Inflammation; Oxidative stress; PI3K; AKT pathway;

D O I：

10.37290/ctnr2641-452X.21:80-85

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Diabetic gastroparesis is a common complication of diabetes that may lead to poor nutrition, problems managing blood glucose, and a reduced quality of life. Jiawei Sijunzi soup has been shown to benefit patients with amyotrophic lateral sclerosis while causing no serious side effects. In this study, we investigated the possible effects of Jiawei Sijunzi soup on the progression of diabetic gastroparesis in a rat model induced by streptozotocin. The results show that Jiawei Sijunzi soup reduced inflammation and oxidative stress and improved the pathological features of gastric tissue in diabetic gastroparesis. The target of Jiawei Sijunzi soup in diabetic gastroparesis was analyzed based on network pharmacology and molecular docking techniques. The results show activation of the PI3K/AKT pathway by Jiawei Sijunzi soup in the rat model of diabetic gastroparesis.

引用

页码：80 / 85

页数：6

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