Challenges and advancements in bioprocess intensification of fungal secondary metabolite: kojic acid

被引:9
|
作者
Sharma, Sumit [1 ]
Singh, Shikha [1 ]
Sarma, Saurabh Jyoti [1 ]
机构
[1] Bennett Univ, Sch Engn & Appl Sci, Dept Biotechnol, Greater Noida 201310, India
来源
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY | 2023年 / 39卷 / 06期
关键词
Kojic acid; Metabolic networks; Genetic regulations; Process improvements; Industrial security; Derivatization; ASPERGILLUS-FLAVUS LINK; AFLATOXIN DEGRADATION ENZYME; LIGNOCELLULOSIC BIOMASS; ANTIMICROBIAL ACTIVITY; BIOSYNTHESIS; FERMENTATION; CARBON; OPTIMIZATION; KINETICS; ORYZAE;
D O I
10.1007/s11274-023-03587-3
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Kojic acid is a fungal secondary metabolite commonly known as a tyrosinase inhibitor, that acts as a skin-whitening agent. Its applications are widely distributed in the area of cosmetics, medicine, food, and chemical synthesis. Renewable resources are the alternative feedstocks that can fulfill the demand for free sugars which are fermented for the production of kojic acid. This review highlights the current progress and importance of bioprocessing of kojic acid from various types of competitive and non-competitive renewable feedstocks. The bioprocessing advancements, secondary metabolic pathway networks, gene clusters and regulations, strain improvement, and process design have also been discussed. The importance of nitrogen sources, amino acids, ions, agitation, and pH has been summarized. Two fungal species Aspergillus flavus and Aspergillus oryzae are found to be extensively studied for kojic acid production due to their versatile substrate utilization and high titer ability. The potential of A. flavus to be a competitive industrial strain for large-scale production of kojic acid has been studied.
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页数:17
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