Two new tetrahydroisoquinoline alkaloids from Portulaca oleracea

被引：2

作者：

Tang, Kai-Jun ^{[1
]}

Chen, Yu ^{[1
]}

Li, Jing ^{[1
]}

Tao, Xu ^{[1
]}

Yang, Lu-Ping ^{[2
]}

Jin, Tian-Yun ^{[3
]}

Zhu, Jia-Shun ^{[1
]}

Zhao, Yu ^{[1
]}

Shen, Tao ^{[1
]}

Wang, Xiao-Ning ^{[1
]}

Ren, Dong-Mei ^{[1
]}

Xiang, Lan ^{[1
]}

机构：

[1] Shandong Univ, Inst Pharmacognosy, Sch Pharmaceut Sci, Key Lab Chem Biol,Minist Educ, Jinan 250012, Shandong, Peoples R China

[2] Shandong Ctr Dis Control & Prevent, Jinan 250014, Shandong, Peoples R China

[3] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, 8655 Kennel Way, La Jolla, CA 92037 USA

来源：

PHYTOCHEMISTRY LETTERS | 2023年 / 53卷

基金：

中国国家自然科学基金;

关键词：

Chemical constituents; Antioxidant; Anti-inflammatory; Portulaca oleracea L; CHEMICAL-CONSTITUENTS; ACIDS; IDENTIFICATION;

D O I：

10.1016/j.phytol.2022.12.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new tetrahydroisoquinoline alkaloids (1-2) were isolated from the edible and ethnomedicinal plant Portulaca oleracea using various chromatographic methods, alongside 53 known compounds (3-55). Their structures were ascribed using extensive NMR, MS and physiochemical analyses with 26 compounds (1-2, 5-6, 8, 10-11, 14-15, 17-18, 20-21, 23, 25-26, 44-53) isolated from P. oleracea for the first time. The potential anti-oxidant and anti-inflammatory applications for P. oleracea were supported by 14 of the isolated compounds (including 1 and 2) displaying DPPH radical-scavenging activities (EC50 = 6.68-64.04 mu M), while a further 18 (including 2) exhibiting NO-inhibiting activities in LPS-stimulated RAW 264.7 macrophage cells (EC50 = 4.25-69.75 mu M).

引用

页码：155 / 160

页数：6

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