Five-Year Safety and Efficacy of Femtosecond Laser-Assisted Descemet Membrane Endothelial Keratoplasty

被引:4
|
作者
Sorkin, Nir [1 ,2 ,3 ]
Gouvea, Larissa [1 ]
Din, Nizar [1 ]
Mimouni, Michael [1 ]
Alshaker, Sara [1 ]
Weill, Yishay [1 ]
Gendler, Shai [1 ]
Slomovic, Allan R. [1 ]
Chan, Clara C. [1 ]
Rootman, David S. [1 ]
机构
[1] Univ Toronto, Dept Ophthalmol & Vis Sci, Toronto, ON, Canada
[2] Tel Aviv Univ, Tel Aviv Med Ctr, Dept Ophthalmol, Tel Aviv, Israel
[3] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
关键词
DMEK; Descemet membrane endothelial keratoplasty; IEK; femtosecond laser; five year; descemetorhexis; Fuchs' dystrophy; OUTCOMES; EYES;
D O I
10.1097/ICO.0000000000003019
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose:The purpose of this study was to evaluate 5-year safety and efficacy outcomes of femtosecond-enabled Descemet membrane endothelial keratoplasty (F-DMEK) in patients with Fuchs' endothelial dystrophy (FED).Methods:This was a retrospective study, including patients with FED and cataract who underwent either F-DMEK (16 eyes of 15 patients) or manual DMEK (M-DMEK) (42 eyes of 37 patients) combined with cataract extraction. Outcome measures included visual acuity, graft detachment, graft survival, and endothelial cell loss.Results:The average follow-up in F-DMEK and M-DMEK was 57.1 +/- 12.4 months and 58.5 +/- 17.3 months, respectively (P = 0.757). The rates of primary failure (0% vs. 9.5%, P = 0.567), secondary failure (0% for both), and graft rejection (0% vs. 7.1%, P = 0.533) did not differ significantly between the groups. Improvement in best spectacle-corrected visual acuity was similar in F-DMEK and M-DMEK (0.32 +/- 0.27 logarithm of the minimum angle of resolution and 0.35 +/- 0.44 logarithm of the minimum angle of resolution, respectively, P = 0.165) and persisted at 2, 3, 4, and 5 years and at the last follow-up. The rates of graft detachment and rebubbling were significantly lower with 6.25% in F-DMEK and 33.3% in M-DMEK (P = 0.035). Cell-loss rates were lower in F-DMEK compared with M-DMEK throughout the follow-up, significantly so up to 2 years with a difference of 8.6% at 1 year (P = 0.023), 11.8% at 2 years (P = 0.021), 7.6% at 3 years (P = 0.088), 5.8% at 4 years (P = 0.256), 13.6% at 5 years (P = 0.169), and 7.1% at the final follow-up (P = 0.341).Conclusions:F-DMEK had an excellent safety and efficacy profile which was maintained over 5 years of follow-up. Lower endothelial cell-loss rates in F-DMEK compared with M-DMEK may help extend the duration of graft survival.
引用
收藏
页码:145 / 149
页数:5
相关论文
共 50 条
  • [1] Femtosecond Laser-Assisted Graft Preparation for Descemet Membrane Endothelial Keratoplasty
    McKee, Hamish D.
    Jhanji, Vishal
    CORNEA, 2018, 37 (10) : 1342 - 1344
  • [2] Outcomes of femtosecond laser-assisted Descemet membrane endothelial keratoplasty for failed penetrating keratoplasty
    Sorkin, Nir
    Trinh, Tanya
    Einan-Lifshitz, Adi
    Mednick, Zale
    Santaella, Gisella
    Telli, Alexandre
    Belkin, Avner
    Chan, Clara C.
    Rootman, David S.
    CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, 2019, 54 (06): : 741 - 745
  • [3] Exploring the precision of femtosecond laser-assisted descemetorhexis in Descemet membrane endothelial keratoplasty
    Pilger, Daniel
    von Sonnleithner, Christoph
    Bertelmann, Eckart
    Maier, Anna-Karina B.
    Joussen, Antonia M.
    Torun, Necip
    BMJ OPEN OPHTHALMOLOGY, 2018, 3 (01):
  • [4] Femtosecond Laser-Assisted Descemetorhexis: A Novel Technique in Descemet Membrane Endothelial Keratoplasty
    Pilger, Daniel
    von Sonnleithner, Christoph
    Bertelmann, Eckart
    Joussen, Antonia M.
    Torun, Necip
    CORNEA, 2016, 35 (10) : 1274 - 1278
  • [5] Comparison of Manual and Femtosecond Laser-Assisted Descemet Membrane Endothelial Keratoplasty for Failed Penetrating Keratoplasty
    Sorkin, Nir
    Mimouni, Michael
    Santaella, Gisella
    Trinh, Tanya
    Cohen, Eyal
    Einan-Lifshitz, Adi
    Chan, Clara C.
    Rootman, David S.
    AMERICAN JOURNAL OF OPHTHALMOLOGY, 2020, 214 : 1 - 8
  • [6] Three-Year Outcome Comparison Between Femtosecond Laser-Assisted and Manual Descemet Membrane Endothelial Keratoplasty
    Sorkin, Nir
    Mednick, Zale
    Einan-Lifshitz, Adi
    Trinh, Tanya
    Santaella, Gisella
    Telli, Alexandre
    Chan, Clara C.
    Rootman, David S.
    CORNEA, 2019, 38 (07) : 812 - 816
  • [7] Preliminary results of femtosecond laser-assisted descemet stripping endothelial keratoplasty
    Cheng, Yanny Y. Y.
    Hendrikse, Fred
    Pels, Elisabeth
    Wijdh, Robert-Jan
    van Cleynenbreugel, Hugo
    Eggink, Cathariena A.
    van Rij, Gabriel
    Rijneveld, Wilhelmina J.
    Nuijts, Rudy M. M. A.
    ARCHIVES OF OPHTHALMOLOGY, 2008, 126 (10) : 1351 - 1356
  • [8] Results of Femtosecond Laser-Assisted Descemet Stripping Automated Endothelial Keratoplasty
    Hosny, Mohamed H.
    Marrie, Ayah
    Sidky, M. Karim
    GamalEldin, Sherif
    Salem, Mohsen
    JOURNAL OF OPHTHALMOLOGY, 2017, 2017
  • [9] RE: "Three-Year Outcome Comparison Between Femtosecond Laser-Assisted and Manual Descemet Membrane Endothelial Keratoplasty"
    Singhal, Deepali
    Maharana, Prafulla K.
    CORNEA, 2019, 38 (11) : E51 - E52
  • [10] RE: "Three-Year Outcome Comparison Between Femtosecond Laser-Assisted and Manual Descemet Membrane Endothelial Keratoplasty" Reply
    Sorkin, Nir
    Mednick, Zale
    Einan-Lifshitz, Adi
    Trinh, Tanya
    Santaella, Gisella
    Telli, Alexandre
    Chan, Clara C.
    Rootman, David S.
    CORNEA, 2019, 38 (11) : E52 - E53