Multi-omics analysis reveals the mechanism of Lacticaseibacillus paracasei IMAUJBC1 in alleviating hyperlipidemia

被引：2

作者：

Cheng, Feng ^{[1
]}

Zhang, Kaiping ^{[2
]}

Yang, Xueqian ^{[1
]}

Shi, Lele ^{[1
]}

Wei, Yaru ^{[1
]}

Wang, Daixun ^{[1
]}

Xia, Lingyan ^{[1
]}

Cao, Kaihui ^{[1
]}

Tian, Jianjun ^{[1
]}

Jin, Ye ^{[1
]}

机构：

[1] Inner Mongolia Agr Univ, Coll Food Sci & Engn, 306 Zhaowuda Rd, Hohhot 010018, Inner Mongolia, Peoples R China

[2] Inner Mongolia Business & Trade Vocat Coll, Dept Cooking & Food Proc, Hohhot 010070, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2024年 / 114卷

基金：

中国国家自然科学基金;

关键词：

Lacticaseibacillus paracasei; Hyperlipidemia; Transcriptome; Lipidome; Microbial diversity; LIVER; MICROBIOME; FABP;

D O I：

10.1016/j.jff.2024.106079

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study investigated the alleviating effect of Lacticaseibacillus paracasei IMAUJBC1 on hyperlipidemia and explored the associated mechanism by combining microbiome, transcriptomic, and lipomic analyses. The highfat mouse model was established with a high-fat diet (HFD), and the intervention of IMAUJBC1 was conducted for 8 weeks after modeling. The results showed that IMAUJBC1 inhibited weight gain and liver fat accumulation in HFD mice, reduced total cholesterol (T-CHO) and low-density lipoprotein cholesterol (LDL-C) serum levels, promoted the conversion of liver cholesterol to total bile acid (TBA), and increased fecal T-CHO excretion. The IMAUJBC1 intervention decreased the ratio of Fumicutes and Bacteroidetes, while the abundance of Alistipes was increased in the mice intestinal microbiome. IMAUJBC1 may alleviate hyperlipidemia through the PPAR signaling pathway, fat digestion and absorption, cholesterol metabolism, and glycerophospholipid metabolism. In summary, IMAUJBC1 can be used as a functional lactobacillus to intervene in hyperlipidemia.

引用

页数：11

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