Retinal optical coherence tomography biomarkers in dementia

被引:0
作者
Goerdt, L. [1 ,3 ]
Holz, F. G. [1 ]
Finger, R. P. [2 ]
机构
[1] Univ Augenklin Bonn, Bonn, Germany
[2] Univ Augenklin Mannheim, Mannheim, Germany
[3] Univ Augenklin Bonn, Ernst Abbe Str 2, D-53127 Bonn, Germany
来源
OPHTHALMOLOGIE | 2024年 / 121卷 / 02期
关键词
Angiographie; Demenz; Netzhaut; Biomarker; Screening; Angiography; Dementia; Retina; Biomarkers; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; THICKNESS;
D O I
10.1007/s00347-023-01947-w
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
BackgroundDue to the general aging of society, the prevalence and incidence of dementia are expected to increase considerably. In order to timely identify patients and assess their need for treatment and/or supportive measures, comprehensive and easy access screening methods are required, which, however, are yet to be developed. To date, several biomarkers for the presence of dementia on high-resolution spectral domain optical coherence tomography (OCT) and OCT angiography (OCT-A) images were identified. AimTo summarize previously identified OCT biomarkers in dementia and to assess their suitability for comprehensive screening examinations. Material and methodsA literature search was conducted on PubMed until March 2023 for the keywords "dementia", "mild cognitive impairment", "OCT", "OCT angiography" and "retinal biomarkers". Relevant publications were identified and summarized. ResultsNumerous unspecific alterations on OCT imaging and OCT-A were identified in patients with (predementia) dementia according to many population and clinical studies. These include a reduced thickness of the peripapillary retinal nerve fiber layer, the ganglion cell complex and the central retinal region. Additionally, a reduced vascular density and an enlarged foveal avascular zone (FAZ) were identified on OCT-A imaging. ConclusionThe currently known OCT biomarkers are too unspecific, and there is to date no OCT or OCT-A-based signature distinguishing between different types of dementia. Further longitudinal studies with larger sample sizes are warranted to develop and evaluate such distinct OCT signatures for different types of dementia and their respective early disease stages and to assess their prognostic value. Only then is the inclusion in comprehensive screening investigations feasible.
引用
收藏
页码:84 / 92
页数:9
相关论文
共 50 条
[41]   Association of Optical Coherence Tomography and Optical Coherence Tomography Angiography Retinal Features With Visual Function in Older Adults [J].
Dong, Yanan ;
Guo, Xinxing ;
Arsiwala-Scheppach, Lubaina T. ;
Sharrett, A. Richey ;
Ramulu, Pradeep Y. ;
Mihailovic, Aleksandra ;
Pan-Doh, Nathan ;
Mosley, Thomas ;
Coresh, Josef ;
Abraham, Alison G. .
JAMA OPHTHALMOLOGY, 2022, 140 (08) :809-817
[42]   Dynamic focus in optical coherence tomography for retinal imaging [J].
Pircher, M. ;
Goetzinger, E. ;
Hitzenberger, C. K. .
JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (05)
[43]   Visual analysis of retinal changes with optical coherence tomography [J].
Martin Röhlig ;
Christoph Schmidt ;
Ruby Kala Prakasam ;
Paul Rosenthal ;
Heidrun Schumann ;
Oliver Stachs .
The Visual Computer, 2018, 34 :1209-1224
[44]   OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VENOUS OCCLUSION [J].
Kashani, Amir H. ;
Lee, Sun Young ;
Moshfeghi, Andrew ;
Durbin, Mary K. ;
Puliafito, Carmen A. .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2015, 35 (11) :2323-2331
[45]   Visual analysis of retinal changes with optical coherence tomography [J].
Roehlig, Martin ;
Schmidt, Christoph ;
Prakasam, Ruby Kala ;
Rosenthal, Paul ;
Schumann, Heidrun ;
Stachs, Oliver .
VISUAL COMPUTER, 2018, 34 (09) :1209-1224
[46]   The Effect of Retinal Melanin on Optical Coherence Tomography Images [J].
Wilk, Melissa A. ;
Huckenpahler, Alison L. ;
Collery, Ross F. ;
Link, Brian A. ;
Carroll, Joseph .
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 2017, 6 (02)
[47]   RETINAL OPTICAL COHERENCE TOMOGRAPHY IN SICKLE CELL DISEASE [J].
Bravo-Filho, Vasco ;
Vilar, Fabiana ;
Martins, Thayze ;
De Biase, Silvio ;
Andrade, Joao ;
Araujo, Aderson ;
Arantes, Tiago .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (15)
[48]   Retinal Layer Segmentation in Optical Coherence Tomography Images [J].
Dodo, Bashir Isa ;
Li, Yongmin ;
Kaba, Djibril ;
Liu, Xiaohui .
IEEE ACCESS, 2019, 7 :152388-152398
[49]   Optical Coherence Tomography Findings in Retinal Artery Occlusion [J].
Feist, Richard M. ;
Mason, John O. ;
Thomley, Martin L. ;
Albert, Michael A. ;
Ayala, Claudia M. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (13)
[50]   Optical coherence tomography findings in chronic progressive external ophthalmoplegia [J].
Wu, Yuan ;
Kang, Lei ;
Wu, Hai-Long ;
Hou, Yue ;
Wang, Zhao-Xia .
CHINESE MEDICAL JOURNAL, 2019, 132 (10) :1202-1207