Poly (vinyl alcohol)-gelatin-sericin copolymerized film fortified with vesicle-entrapped demethoxycurcumin/bisdemethoxycurcumin for improved stability, antibacterial, anti-inflammatory, and skin tissue regeneration

被引：37

作者：

Singh, Sudarshan ^{[1
,2
,3
,4
]}

Supaweera, Nassareen ^{[1
]}

Nwabor, Ozioma F. ^{[5
]}

Chaichompoo, Waraluck ^{[6
]}

Suksamrarn, Apichart ^{[7
,8
]}

Chittasupho, Chuda ^{[4
]}

Chunglok, Warangkana ^{[1
,2
]}

机构：

[1] Walailak Univ, Sch Allied Hlth Sci, Nakhon Si Thammarat 80160, Thailand

[2] Walailak Univ, Food Technol & Innovat Res Ctr Excellence, Res & Innovat Inst Excellence, Nakhon Si Thammarat 80160, Thailand

[3] Chiang Mai Univ, Off Res Adm, Chiang Mai 50200, Thailand

[4] Chiang Mai Univ, Fac Pharm, Chiang Mai 50200, Thailand

[5] Syracuse Univ, Coll Engn & Comp Sci, Dept Biomed & Chem Engn, Syracuse, NY 13244 USA

[6] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Food & Pharmaceut Chem, Bangkok 10330, Thailand

[7] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok 10240, Thailand

[8] Ramkhamhang Univ, Fac Sci, Ctr Excellence Innovat Chem, Bangkok 10240, Thailand

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 258卷

关键词：

Anti-inflammatory; Bisdemethoxycurcumin; Curcuminoids; Cellular uptake; Demethoxycurcumin; Vesicles; IN-VITRO; CURCUMA-LONGA; DEMETHOXYCURCUMIN; NANOPARTICLES; BISDEMETHOXYCURCUMIN; ANALOGS; ACID;

D O I：

10.1016/j.ijbiomac.2023.129071

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vesicle delivery carriers, used to stabilize hydrophobic drugs, are characterized by the propensity to aggregate, and fuse, limiting its applications. Fortifying vesicle-entrapped drugs within a biodegradable polymeric film constitutes a promising solution. In this study, biodegradable poly (vinyl alcohol) copolymerized with gelatinsericin film and integrated alongside vesicle-entrapped demethoxycurcumin (DMC) or bisdemethoxycurcumin (BDMC) was developed, extensively characterized for improve efficacy, and compared. Vesicle-entrapped DMC or BDMC was spherical in shape with no changes in size, zeta-potential, and morphology after storing at 4degree celsius for 30 days. Antibacterial activity of vesicle-entrapped DMC formulations against Acinetobacter baumannii and Staphylococcus epidermidis was more effective than that of its free form. DMC and BDMC demonstrated dose dependent reduction in lipopolysaccharides (LPS)-induced nitric oxide (NO) levels either in free or in entrapped form. Moreover, vesicle-entrapped DMC/BDMC suppressed NO production at lower concentrations, compared with that of their free form and significantly improved the viability of RAW264.7 and HaCaT cells. Furthermore, functionalized film with vesicle-entrapped DMC/BDMC demonstrated excellent radical scavenging, biocompatibility, and cell migration efficacy. Thus, incorporating vesicle, entrapped DMC/BDMC within biodegradable polymeric film may comprised a promising strategy for improving stability, wound healing, and inflammation attenuation efficacy.

引用

页数：16

共 61 条

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