Current status of research on endophytes of traditional Tibetan medicinal plant and their metabolites

被引:4
作者
Hu, Danni [1 ]
Long, Xintong [1 ]
Luobu, Tudan [2 ]
Wang, Qi [1 ]
机构
[1] Wuhan Univ Technol, Wuhan, Peoples R China
[2] Tibetan Hosp Gongga Cty, Pharm Dept, Shannan, Peoples R China
关键词
Qinghai-Tibet Plateau; Tibetan medicinal plants; Endophytes; Metabolites; Resource conservation; SAUSSUREA-MEDUSA; BACCATIN-III; FUNGUS; DIVERSITY; GROWTH; PODOPHYLLOTOXIN; PHYTOCHEMISTRY; CONSTITUENTS; PHARMACOLOGY; PEIMISINE;
D O I
10.1007/s13205-023-03720-x
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The Qinghai-Tibet Plateau, known as the "Third Pole of the World," has a rich variety of medicinal plants that play an important role in the field of medicine due to its unique geographical environment. However, due to the limited resources of Tibetan medicinal plants and the fragility of the ecological environment of the Qinghai-Tibet Plateau, more and more Tibetan medicinal plants are on the verge of extinction. As a reservoir of biologically active metabolites, endophytes of medicinal plants produce a large number of compounds with potential applications in modern medicine (including antibacterial, immunosuppressive, antiviral, and anticancer) and are expected to be substitutes for Tibetan medicinal plants. This paper reviews 12 Tibetan medicinal plants from the Qinghai-Tibet Plateau, highlighting the diversity of their endophytes, the diversity of their metabolites and their applications. The results show that the endophytes of Tibetan medicinal plants are remarkably diverse, and the efficacy of their metabolites involves various aspects, such as antioxidant, anti-disease and anti-parasitic. In addition, conservation measures for the resources of Tibetan medicinal plants are summarised to provide a reference for an in-depth understanding of the endophytes of Tibetan medicinal plants and to stimulate the scientific community to bioprospect for the endophytes of Tibetan medicinal plants, as well as to provide ideas for their rational exploitation.
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页数:17
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共 110 条
  • [1] Microbial Natural Products in Drug Discovery
    Abdel-Razek, Ahmed S.
    El-Naggar, Mehrez E.
    Allam, Ahmed
    Morsy, Osama M.
    Othman, Sarah I.
    [J]. PROCESSES, 2020, 8 (04)
  • [2] Plant beneficial endophytic bacteria: Mechanisms, diversity, host range and genetic determinants
    Afzal, Imran
    Shinwari, Zabta Khan
    Sikandar, Shomaila
    Shahzad, Shaheen
    [J]. MICROBIOLOGICAL RESEARCH, 2019, 221 : 36 - 49
  • [3] [Anonymous], 1868, Morphologie und physiologie der Pilze
  • [4] Neuroprotective Secondary Metabolite Produced by an Endophytic Fungus, Neosartorya fischeri JS']JS0553, Isolated from Glehnia littoralis
    Bang, Sunghee
    Song, Ji Hoon
    Lee, Dahae
    Lee, Changyeol
    Kim, Soonok
    Kang, Ki Sung
    Lee, Jong Hun
    Shim, Sang Hee
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 67 (07) : 1831 - 1838
  • [5] Climatic and associated cryospheric, biospheric, and hydrological changes on the Tibetan Plateau: a review
    Bibi, Sadia
    Wang, Lei
    Li, Xiuping
    Zhou, Jing
    Chen, Deliang
    Yao, Tandong
    [J]. INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2018, 38 : E1 - E17
  • [6] Asperpyrone F, a new dimeric naphtho-γ-pyrone from the edible fungus Pleurotus ostreatus
    Cai, Xu
    Yu, Yang
    Li, Qian
    Chen, Ben-Ke
    Huang, Yun
    Zou, Xian-Wei
    Tang, Jin-Tian
    Huang, Bi-Sheng
    [J]. NATURAL PRODUCT RESEARCH, 2019, 33 (13) : 1953 - 1960
  • [7] Chen Jing, 2017, Zhongguo Zhong Yao Za Zhi, V42, P4582, DOI 10.19540/j.cnki.cjcmm.20171030.013
  • [8] Chinese Pharmacopoeia Commission, 2015, Chinese Pharmacopoeia
  • [9] Diversity and Antioxidant Activity of Culturable Endophytic Fungi from Alpine Plants of Rhodiola crenulata, R-angusta, and R-sachalinensis
    Cui, Jin-Long
    Guo, Ting-Ting
    Ren, Zhen-Xing
    Zhang, Na-Sha
    Wang, Meng-Liang
    [J]. PLOS ONE, 2015, 10 (03):
  • [10] Current Status and Medicinal Prominence of Arnebia euchroma (Ratanjot): A Critically Endangered Plant of Trans-Himalayan Region
    Devi S.
    Sharma P.
    Sharma R.
    Thakur M.
    [J]. Recent Patents on Biotechnology, 2023, 17 (01) : 92 - 102