Multiscale investigation of viscoelastic properties of aqueous solutions of sodium alginate and evaluation of their biocompatibility

被引：8

作者：

Varela-Feijoo, Alberto ^{[1
,2
,8
]}

Djemia, Philippe ^{[3
]}

Narita, Tetsuharu ^{[4
]}

Pignon, Frederic ^{[5
]}

Baeza-Squiban, Armelle ^{[6
,7
]}

Sirri, Valentina ^{[6
,7
]}

Ponton, Alain ^{[1
,2
]}

机构：

[1] Univ Paris Cite, Lab Matiere & Syst Complexes, F-75013 Paris, France

[2] CNRS, UMR 7057, 10 Rue A Domon & L Duquet, F-75013 Paris, France

[3] UPR CNRS 3407, Lab Sci Procedes & Mat LSPM, 99 Ave Jean Baptiste Clement, F-93530 Villetaneuse, France

[4] Ecole Super Phys & Chim Ind Ville Paris ESPCI, 10 Rue Vauquelin, F-75005 Paris, France

[5] Univ Grenoble Alpes, CNRS, UMR 5520, Lab Rheol & Procedes LPG, 5520 Domaine Univ,BP 53, F-38041 Grenoble 9, France

[6] Univ Paris Cite, Unite Biol Fonct & Adaptat BFA, F-75013 Paris, France

[7] CNRS, UMR 8251, 4 Rue Marie Andree Lagroua Weill Halle, F-75013 Paris, France

[8] Univ Paris Saclay, INRAE, AgroParisTech, UMR SayFood, F-91120 Palaiseau, France

来源：

SOFT MATTER | 2023年 / 19卷 / 31期

关键词：

RHEOLOGICAL PROPERTIES; SMALL-ANGLE; BEHAVIOR; SCATTERING; VISCOSITY; RESIDUES;

D O I：

10.1039/d3sm00159h

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In order to get better knowledge of mechanical properties from microscopic to macroscopic scale of biopolymers, viscoelastic bulk properties of aqueous solutions of sodium alginate were studied at different scales by combining macroscopic shear rheology (Hz), diffusing-wave spectroscopy microrheology (kHz-MHz) and Brillouin spectroscopy (GHz). Structural properties were also directly probed by small-angle X-ray scattering (SAXS). The results demonstrate a change from polyelectrolyte behavior to neutral polymer behavior by increasing polymer concentration with the determination of characteristic sizes (persistence length, correlation length). The viscoelastic properties probed at the phonon wavelength much higher than the ones obtained at low frequency reflect the variation of microscopic viscosity. First experiments obtained by metabolic activity assays with mouse embryonic fibroblasts showed biocompatibility of sodium alginate aqueous solutions in the studied range of concentrations (2.5-10 g L-1) and consequently their potential biomedical applications.

引用

页码：5942 / 5955

页数：14

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