Prognostic Value of Insulin Resistance Assessed by HOMA-IR in Non-Diabetic Patients with Decompensated Heart Failure

The predictive value of insulin resistance in patients hospitalized with heart failure is unknown. To evaluate prognostic value of insulin resistance (defined by a HOMA IR > 2.5) for the combined event of death and readmission at 90 and 365 days post discharge and to determine if there are differences according to ejec-tion fraction. Prospective study of 156 p hospitalized for acute heart failure without diabetes. A total of 83 years, 48% female, EF < 45% 48%. Of 28% presented HOMA >2.5. HOMA IR >2.5 was associated with com-bined event (OR 2.4; 95% CI 1.9-5.1; P: 0.02) at 90 days. A multivariate analysis demonstrated its inde-pendent predictive value (OR 2.5, 95% CI 1.1-5.8; P: 0.03). At 1 year follow-up HOMA IR did not predict events. The predictive value of HOMA-IR was not asso-ciated with ventricular function. HOMA IR index was a predictor of a combined event at 90 days in our popula-tion. It is a simple determination that could contribute to identify higher risk patients during this vulnerable post-discharge phase. These data must be validated in larger studies. (Curr Probl Cardiol 2023;48:101112.)