Genomic Surveillance of SARS-CoV-2 in Healthcare Workers: A Critical Sentinel Group for Monitoring the SARS-CoV-2 Variant Shift

被引：4

作者：

Padilha, Dayane Azevedo ^{[1
]}

Souza, Doris Sobral Marques ^{[1
]}

Kawagoe, Eric Kazuo ^{[1
]}

Benetti Filho, Vilmar ^{[1
]}

Amorim, Ariane Nicaretta ^{[1
]}

Barazzetti, Fernando Hartmann ^{[2
]}

Schorner, Marcos Andre ^{[2
]}

Fernandes, Sandra Bianchini ^{[3
]}

Coelho, Bruna Kellet ^{[3
]}

Rovaris, Darcita Buerger ^{[3
]}

Dos Anjos, Marlei Pickler Debiase ^{[3
]}

Moser, Juliana Righetto ^{[4
]}

Melo, Fernanda Rosene ^{[4
]}

De Souza, Bianca Bittencourt ^{[4
]}

Bessa, Dimitri da Costa ^{[4
]}

Mendes, Fernando Henrique de Paula e Silva ^{[4
]}

Boing, Alexandra Crispim ^{[2
]}

Boing, Antonio Fernando ^{[2
]}

de Lacerda, Josimari Telino ^{[2
]}

Moura, Guilherme Valle ^{[5
]}

De Bastiani, Daniela Carolina ^{[6
]}

de Moraes, Milene Hoehr ^{[6
]}

De Oliveira, Luiz Felipe Valter ^{[6
]}

Moreira, Renato Simoes ^{[7
]}

Stoco, Patricia Hermes ^{[1
]}

Bazzo, Maria Luiza ^{[2
]}

Fongaro, Gislaine ^{[1
]}

Wagner, Glauber ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Ctr Ciencias Biol, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Ctr Ciencias Saude, BR-88040370 Florianopolis, SC, Brazil

[3] Lab Cent Estado Saude Santa Catarina, BR-88010001 Florianopolis, SC, Brazil

[4] Diretoria Vigilancia Epidemiol Santa Catarina, BR-88015130 Florianopolis, SC, Brazil

[5] Univ Fed Santa Catarina, Ctr Socio Econ, BR-88040900 Florianopolis, SC, Brazil

[6] Biome Hub Pesquisa & Desenvolvimento, BR-88054700 Florianopolis, SC, Brazil

[7] Inst Fed Santa Catarina, BR-89111009 Gaspar, SC, Brazil

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 04期

关键词：

healthcare workers; SARS-CoV-2; variants; Omicron; sentinel groups; COVID-19;

D O I：

10.3390/v15040984

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

SARS-CoV-2 genome surveillance is important for monitoring risk groups and health workers as well as data on new cases and mortality rate due to COVID-19. We characterized the circulation of SARS-CoV-2 variants from May 2021 to April 2022 in the state of Santa Catarina, southern Brazil, and evaluated the similarity between variants present in the population and healthcare workers (HCW). A total of 5291 sequenced genomes demonstrated the circulation of 55 strains and four variants of concern (Alpha, Delta, Gamma and Omicron-sublineages BA.1 and BA.2). The number of cases was relatively low in May 2021, but the number of deaths was higher with the Gamma variant. There was a significant increase in both numbers between December 2021 and February 2022, peaking in mid-January 2022, when the Omicron variant dominated. After May 2021, two distinct variant groups (Delta and Omicron) were observed, equally distributed among the five Santa Catarina mesoregions. Moreover, from November 2021 to February 2022, similar variant profiles between HCW and the general population were observed, and a quicker shift from Delta to Omicron in HCW than in the general population. This demonstrates the importance of HCW as a sentinel group for monitoring disease trends in the general population.

引用

页数：11

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