Two Cases of Immune Checkpoint Inhibitor- Induced Myocarditis With Complete Atrioventricular Block

被引：6
作者：
Kondo, Hisaya [1 ]
Kirigaya, Jin [2 ]
Matsuzawa, Yasushi [1 ]
Hibi, Kiyoshi [1 ]
机构：
[1] Yokohama City Univ, Cardiol, Med Ctr, Yokohama, Japan
[2] Yokohama City Univ, Emergency & Crit Care, Med Ctr, Yokohama, Japan
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 03期
关键词：
myocarditis; immune-related adverse event; complete atrioventricular block; cardio-oncology; case report;
D O I：
10.7759/cureus.36446
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Immune checkpoint inhibitor-induced myocarditis (ICIM) has been reported to be complicated by a complete atrioventricular block. Even though steroids are used in the treatment thereof, there is no standard protocol for their use. We report two cases of ICIM with a complete atrioventricular block with different outcomes. In the first case, the complete atrioventricular block did not recover. In contrast, in the second case, the complete atrioventricular block did recover. We discuss the different courses and outcomes of the two cases in relation to steroid use.
引用
收藏
页数：9
相关论文
共 50 条
[41]   Rechallenge After Severe Immune Checkpoint Inhibitor Myocarditis Venturing Into the Unknown [J].
Bailly, Guillaume ;
Robert-Halabi, Maxime ;
Vion, Pierre-Adrien ;
Allenbach, Yves ;
Abbar, Baptiste ;
Bretagne, Marie ;
Salem, Joe-Elie .
JACC: CARDIOONCOLOGY, 2025, 7 (03) :300-304
[42]   Myocarditis: A Rare Complication of Immune Checkpoint Inhibitor Therapy [J].
Nair, Devi Parvathy Jyothi Ramachandran ;
Zachariah, Shilla ;
Scollan, David ;
Shaikh, Atif .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (05)
[43]   Updates in Diagnosis and Treatment of Immune Checkpoint Inhibitor Myocarditis [J].
Hachem, Anthony M. ;
Desai, Aditya ;
Beinart, Noah ;
Ostos-Mendoza, Keila C. ;
Rodriguez, Ana Sofia Lopez ;
Derby, Regina Diaz de Leon ;
Ebrahimi, Sara ;
Palaskas, Nicolas L. .
CURRENT CARDIOLOGY REPORTS, 2025, 27 (01)
[44]   Immune checkpoint inhibitor induced myocarditis, myasthenia gravis, and myositis: A single-center case series [J].
Longinow, Joshua ;
Zmaili, Mohammad ;
Skoza, Warren ;
Kondoleon, Nicholas ;
Marquardt, Robert ;
Calabrese, Cassandra ;
Funchain, Pauline ;
Moudgil, Rohit .
CANCER MEDICINE, 2023, 12 (03) :2281-2289
[45]   Relevance of surveillance manual for the early detection of immune checkpoint inhibitor-induced myocarditis: A case series [J].
Oyakawa, Takuya ;
Muraoka, Nao ;
Iida, Kei ;
Fujita, Ayano ;
Yokoyama, Koichi ;
Ishikawa, Hiroshi ;
Murakami, Haruyasu .
ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING, 2024, 11 (11)
[46]   What Is the Evidence of the Diagnostic Criteria and Screening of Immune Checkpoint Inhibitor-Induced Myocarditis? [J].
Thuny, Franck ;
Bonaca, Marc P. ;
Cautela, Jennifer .
JACC: CARDIOONCOLOGY, 2022, 4 (05) :624-628
[47]   Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor-Induced Myocarditis [J].
Zhu, Han ;
Galdos, Francisco X. ;
Lee, Daniel ;
Waliany, Sarah ;
Huang, Yuhsin Vivian ;
Ryan, Julia ;
Dang, Katherine ;
Neal, Joel W. ;
Wakelee, Heather A. ;
Reddy, Sunil A. ;
Srinivas, Sandy ;
Lin, Lih-Ling ;
Witteles, Ronald M. ;
Maecker, Holden T. ;
Davis, Mark M. ;
Nguyen, Patricia K. ;
Wu, Sean M. .
CIRCULATION, 2022, 146 (04) :316-335
[48]   Immune checkpoint inhibitor-induced myasthenia gravis, myocarditis, and myositis: A case report [J].
Basnet, Arjun ;
Sharma, Nava Raj ;
Gautam, Sudarshan ;
Lamichhane, Saral ;
Kansakar, Sajog ;
Tiwari, Kripa ;
Pokhrel, Madalasa ;
Singh, Sehajpreet .
CLINICAL CASE REPORTS, 2024, 12 (06)
[49]   Refractory right ventricular myocarditis induced by immune checkpoint inhibitor despite therapy cessation and immune suppression [J].
Khan O. Mohammad ;
Hanna Fanous ;
Sneha Vakamudi ;
Yan Liu .
Cardio-Oncology, 9
[50]   Refractory right ventricular myocarditis induced by immune checkpoint inhibitor despite therapy cessation and immune suppression [J].
Mohammad, Khan O. ;
Fanous, Hanna ;
Vakamudi, Sneha ;
Liu, Yan .
CARDIO-ONCOLOGY, 2023, 9 (01)
12345