Two Cases of Immune Checkpoint Inhibitor- Induced Myocarditis With Complete Atrioventricular Block

被引:5
作者
Kondo, Hisaya [1 ]
Kirigaya, Jin [2 ]
Matsuzawa, Yasushi [1 ]
Hibi, Kiyoshi [1 ]
机构
[1] Yokohama City Univ, Cardiol, Med Ctr, Yokohama, Japan
[2] Yokohama City Univ, Emergency & Crit Care, Med Ctr, Yokohama, Japan
关键词
myocarditis; immune-related adverse event; complete atrioventricular block; cardio-oncology; case report;
D O I
10.7759/cureus.36446
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Immune checkpoint inhibitor-induced myocarditis (ICIM) has been reported to be complicated by a complete atrioventricular block. Even though steroids are used in the treatment thereof, there is no standard protocol for their use. We report two cases of ICIM with a complete atrioventricular block with different outcomes. In the first case, the complete atrioventricular block did not recover. In contrast, in the second case, the complete atrioventricular block did recover. We discuss the different courses and outcomes of the two cases in relation to steroid use.
引用
收藏
页数:9
相关论文
共 50 条
[31]   Immune checkpoint inhibitor-induced myocarditis in lung cancer patients: a case report of sintilimab-induced myocarditis and a review of the literature [J].
Bi, Huanhuan ;
Ren, Dunqiang ;
Wang, Qiang ;
Ding, Xiaoqian ;
Wang, Hongmei .
ANNALS OF PALLIATIVE MEDICINE, 2021, 10 (01) :793-802
[32]   Myocarditis and myasthenia gravis induced by immune checkpoint inhibitor in a patient with relapsed thymoma: A case report [J].
Zhong, Peng ;
Zhang, Cuizhen ;
Guan, Hongshan ;
Yan, Jie ;
He, Mengying ;
Zhou, Xiaoyang .
CLINICAL CASE REPORTS, 2023, 11 (03)
[33]   Complete Atrioventricular Block in COVID-19-Related Myocarditis: A Case Report [J].
Amir, Muzakkir .
IRANIAN HEART JOURNAL, 2023, 24 (02) :108-113
[34]   Complete atrioventricular block persisting after regression of infectious myocarditis [J].
Maury, Philippe ;
Chilon, Talia ;
Dumonteil, Nicolas ;
Fontan, Anthony .
JOURNAL OF ELECTROCARDIOLOGY, 2008, 41 (06) :665-667
[35]   Pathological Features of Complete Atrioventricular Block in Dogs with Lymphocytic Myocarditis [J].
Sasaki, T. ;
Saeki, C. ;
Hirakawa, A. ;
Machida, N. .
JOURNAL OF COMPARATIVE PATHOLOGY, 2020, 174 :18-25
[36]   Biomarker Trends, Incidence, and Outcomes of Immune Checkpoint Inhibitor-Induced Myocarditis [J].
Vasbinder, Alexi ;
Chen, YeeAnn ;
Procureur, Adrien ;
Gradone, Allison ;
Azam, Tariq U. ;
Perry, Daniel ;
Shadid, Husam ;
Anderson, Elizabeth ;
Catalan, Tonimarie ;
Blakely, Pennelope ;
Nelapudi, Namratha ;
Fardous, Mohamad ;
Bretagne, Marie C. ;
Adie, Sarah K. ;
Pogue, Kristen T. ;
Leja, Monika ;
Yentz, Sarah ;
Schneider, Bryan ;
Fecher, Leslie A. ;
Lao, Christopher D. ;
Salem, Joe-Elie ;
Hayek, Salim S. .
JACC: CARDIOONCOLOGY, 2022, 4 (05) :689-700
[37]   Immune-Checkpoint Inhibitor-Induced Fulminant Myocarditis and Cardiogenic Shock [J].
Ben Zadok, Osnat Itzhaki ;
Ben-Avraham, Ben ;
Nohria, Anju ;
Orvin, Katia ;
Nassar, Mithal ;
Iakobishvili, Zaza ;
Neiman, Victoria ;
Goldvaser, Hadar ;
Kornowski, Ran ;
Ben Gal, Tuvia .
JACC: CARDIOONCOLOGY, 2019, 1 (01) :141-144
[38]   Immune Checkpoint Inhibitor-Induced Myocarditis vs. COVID-19 Vaccine-Induced Myocarditis-Same or Different? [J].
Zornitzki, Lior ;
Havakuk, Ofer ;
Rozenbaum, Zach ;
Viskin, Dana ;
Arbel, Yaron ;
Flint, Nir ;
Arnold, Joshua ;
Waissengein, Barliz ;
Wolf, Ido ;
Banai, Shmuel ;
Topilsky, Yan ;
Laufer-Perl, Michal .
LIFE-BASEL, 2022, 12 (09)
[39]   Immune Checkpoint Inhibitor-Related Myocarditis: Recognition Surveillance, and Management [J].
Kuhnly, Nicole M. ;
Coviello, Jessica Shank .
CLINICAL JOURNAL OF ONCOLOGY NURSING, 2022, 26 (01) :54-60
[40]   Immune checkpoint inhibitor-associated myocarditis: a novel risk score [J].
Power, John R. ;
Dolladille, Charles ;
Ozbay, Benay ;
Procureur, Adrien ;
Ederhy, Stephane ;
Palaskas, Nicolas L. ;
Lehmann, Lorenz H. ;
Cautela, Jennifer ;
Courand, Pierre-Yves ;
Hayek, Salim S. ;
Zhu, Han ;
Zaha, Vlad G. ;
Cheng, Richard K. ;
Alexandre, Joachim ;
Roubille, Francois ;
Baldassarre, Lauren A. ;
Chen, Yen-Chou ;
Baik, Alan H. ;
Laufer-Perl, Michal ;
Tamura, Yuichi ;
Asnani, Aarti ;
Francis, Sanjeev ;
Gaughan, Elizabeth M. ;
Rainer, Peter P. ;
Bailly, Guillaume ;
Flint, Danette ;
Arangalage, Dimitri ;
Cariou, Eve ;
Florido, Roberta ;
Narezkina, Anna ;
Liu, Yan ;
Sandhu, Shahneen ;
Leong, Darryl ;
Issa, Nahema ;
Piriou, Nicolas ;
Heinzerling, Lucie ;
Peretto, Giovanni ;
Crusz, Shanthini M. ;
Akhter, Nausheen ;
Levenson, Joshua E. ;
Turker, Isik ;
Eslami, Assie ;
Fenioux, Charlotte ;
Moliner, Pedro ;
Obeid, Michel ;
Chan, Wei Ting ;
Ewer, Stephen M. ;
Kassaian, Seyed Ebrahim ;
Johnson, Douglas B. ;
Nohria, Anju .
EUROPEAN HEART JOURNAL, 2025,