Two Cases of Immune Checkpoint Inhibitor- Induced Myocarditis With Complete Atrioventricular Block

被引:5
|
作者
Kondo, Hisaya [1 ]
Kirigaya, Jin [2 ]
Matsuzawa, Yasushi [1 ]
Hibi, Kiyoshi [1 ]
机构
[1] Yokohama City Univ, Cardiol, Med Ctr, Yokohama, Japan
[2] Yokohama City Univ, Emergency & Crit Care, Med Ctr, Yokohama, Japan
关键词
myocarditis; immune-related adverse event; complete atrioventricular block; cardio-oncology; case report;
D O I
10.7759/cureus.36446
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Immune checkpoint inhibitor-induced myocarditis (ICIM) has been reported to be complicated by a complete atrioventricular block. Even though steroids are used in the treatment thereof, there is no standard protocol for their use. We report two cases of ICIM with a complete atrioventricular block with different outcomes. In the first case, the complete atrioventricular block did not recover. In contrast, in the second case, the complete atrioventricular block did recover. We discuss the different courses and outcomes of the two cases in relation to steroid use.
引用
收藏
页数:9
相关论文
共 50 条
  • [1] Checkpoint inhibitor-induced fulminant myocarditis, complete atrioventricular block and myasthenia gravis-a case report
    Portoles Hernandez, Antonio
    Blanco Clemente, Mariola
    Escribano Garcia, Daniel
    Velasco Calvo, Rocio
    Nunez Garcia, Beatriz
    Oteo Dominguez, Juan Francisco
    Salas Anton, Clara
    Mendez Garcia, Miriam
    Segovia Cubero, Javier
    Dominguez, Fernando
    CARDIOVASCULAR DIAGNOSIS AND THERAPY, 2021, 11 (04) : 1013 - 1019
  • [2] Complete heart block is a significant predictor of mortality in immune checkpoint inhibitor myocarditis
    O'Shea, Michael P.
    Karikalan, Suganya Arunachalam
    Yusuf, Ali
    Barry, Timothy
    Habib, Eiad
    O'Shea, John
    Killian, Michael
    Baqal, Eman
    Nayak, Srishti
    Masson, Rajeev
    Hermann, Joerg
    Shah, Shimoli
    Ayoub, Chadi
    Masry, Hicham El
    CARDIO-ONCOLOGY, 2023, 9 (01)
  • [3] Complete heart block is a significant predictor of mortality in immune checkpoint inhibitor myocarditis
    Michael P. O’Shea
    Suganya Arunachalam Karikalan
    Ali Yusuf
    Timothy Barry
    Eiad Habib
    John O’Shea
    Michael Killian
    Eman Baqal
    Srishti Nayak
    Rajeev Masson
    Joerg Hermann
    Shimoli Shah
    Chadi Ayoub
    Hicham El Masry
    Cardio-Oncology, 9
  • [4] Immune checkpoint inhibitor myocarditis
    Raikhelkar, Jayant
    Uriel, Nir
    CURRENT OPINION IN CARDIOLOGY, 2019, 34 (03) : 303 - 306
  • [5] Myocarditis induced by immune checkpoint inhibitor therapy
    Baig, Muhammad Akbar
    Brambl, Wells
    Heuser, William
    CLINICAL TOXICOLOGY, 2022, 60 : 118 - 119
  • [6] Pathophysiology of Immune Checkpoint Inhibitor-Induced Myocarditis
    Jimenez-Alejandre, Rosa
    Ruiz-Fernandez, Ignacio
    Martin, Pilar
    CANCERS, 2022, 14 (18)
  • [7] Overcoming challenges of immune checkpoint inhibitor-induced myocarditis diagnosis
    Cautela, Jennifer
    Deharo, Francois
    Thuny, Franck
    ARCHIVES OF CARDIOVASCULAR DISEASES, 2023, 116 (10) : 429 - 432
  • [8] Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis
    Power, John R.
    Alexandre, Joachim
    Choudhary, Arrush
    Ozbay, Benay
    Hayek, Salim
    Asnani, Aarti
    Tamura, Yuichi
    Aras, Mandar
    Cautela, Jennifer
    Thuny, Franck
    Gilstrap, Lauren
    Arangalage, Dimitri
    Ewer, Steven
    Huang, Shi
    Deswal, Anita
    Palaskas, Nicolas L.
    Finke, Daniel
    Lehmann, Lorenz
    Ederhy, Stephane
    Moslehi, Javid
    Salem, Joe-Elie
    CIRCULATION, 2021, 144 (18) : 1521 - 1523
  • [9] Coexistence of Anti-PD1-Induced Immune Myocarditis and Complete Atrioventricular Block: A Case Report
    Gurdogan, Muhammet
    Yalta, Kenan
    Gurlertop, Yekta
    Karahan, Furkan
    Bulburu, Irem Bilge
    Kocyogot, Beliz
    Ustabasioglu, Fethi Emre
    Cicin, Irfan
    AMERICAN JOURNAL OF CARDIOLOGY, 2023, 207 : 35 - 38
  • [10] Complete atrioventricular block in experimental murine myocarditis
    Ohmae, M
    Kishimoto, C
    Tomioka, N
    JOURNAL OF ELECTROCARDIOLOGY, 2005, 38 (03) : 230 - 234