Tissue engineering in reconstructive urology-The current status and critical insights to set future directions-critical review

被引:6
作者
Lawkowska, Karolina [1 ]
Rosenbaum, Clemens [2 ]
Petrasz, Piotr [3 ]
Kluth, Luis [5 ]
Koper, Krzysztof [4 ]
Drewa, Tomasz [1 ]
Pokrywczynska, Marta [1 ]
Adamowicz, Jan [1 ]
机构
[1] Nicolaus Copernicus Univ, Dept Regenerat Med, Coll Med, Bydgoszcz, Poland
[2] Asklepios Klin Barmbek Germany, Dept Urol, Hamburg, Germany
[3] Voivodeship Hosp Gorzow Wielkopolski, Dept Urol, Gorzow Wielkopolski, Poland
[4] Nicolaus Copernicus Univ, Dept Clin Oncol & Nursing, Coll Med, Curie Sklodowskiej 9, Bydgoszcz, Poland
[5] Univ Med Ctr Frankfurt, Dept Urol, Frankfurt, Germany
关键词
tissue engineering; reconstructive urology; regenerative medicine; urology; biomaterials; MESENCHYMAL STEM-CELLS; STRESS URINARY-INCONTINENCE; ENDOTHELIAL GROWTH-FACTOR; SMOOTH-MUSCLE-CELLS; SMALL-INTESTINE SUBMUCOSA; TERM-FOLLOW-UP; BUCCAL MUCOSA; IN-VITRO; AMNIOTIC MEMBRANE; URETERAL RECONSTRUCTION;
D O I
10.3389/fbioe.2022.1040987
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Advanced techniques of reconstructive urology are gradually reaching their limits in terms of their ability to restore urinary tract function and patients' quality of life. A tissue engineering-based approach to urinary tract reconstruction, utilizing cells and biomaterials, offers an opportunity to overcome current limitations. Although tissue engineering studies have been heralding the imminent introduction of this method into clinics for over a decade, tissue engineering is only marginally applied. In this review, we discuss the role of tissue engineering in reconstructive urology and try to answer the question of why such a promising technology has not proven its clinical usability so far.
引用
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页数:23
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