NIR-II Luminescent and Multi-Responsive Rare Earth Nanocrystals for Improved Chemodynamic Therapy

被引:8
作者
Wei, Zixiang [1 ]
Chao, Zhicong [2 ]
Zhang, Xindan [2 ]
Yu, Jiantao [2 ]
Xiao, Fan [2 ]
Zhang, Xuanjun [1 ]
Tian, Leilei [2 ]
机构
[1] Univ Macau, Fac Hlth Sci, Taipa 999078, Macau, Peoples R China
[2] Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
chemodynamic therapy; rare-earth nanocrystal; up-conversion emission; NIR-II fluorescence; DNA nanotechnology; FENTON REACTION; CANCER-THERAPY; NANOPARTICLES; DELIVERY; ASCORBATE;
D O I
10.1021/acsami.2c22260
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
mediated Fenton reaction can amplify intracellular oxidative stress by producing toxic center dot OH. However, the high-dose need for Fe2+ delivery in tumors and its significant cytotoxicity to normal tissues set a challenge. Therefore, a controllable delivery to activate the Fenton reaction and enhance Fe2+ tumor accumulation has become an approach to solve this conflict. Herein, we report a rare-earthtechniques and DNA nanotechnology to realize programmable Fe2+ delivery. Ferrocenes, the source of Fe2+, are modified on the surface of RENCs through pH-responsive DNAs, which are further shielded by a PEG layer to elongate blood circulation and "turn off" the cytotoxicity of ferrocene. The up-/down-conversion dual-mode emissions of RENCs endow the delivery system with both capabilities of diagnosis and delivery control. The down-conversion NIR-II fluorescence can locate tumors. Consequently, upconversion UV light spatiotemporally activates the catalytic activity of Fe2+ by shedding off the protective PEG layer. The exposed ferrocene-DNAs not only can "turn on" Fenton catalytic activity but also respond to tumor acidity, driving cross-linking and enhanced Fe2+ enrichment in tumors by 4.5-fold. Accordingly, this novel design concept will be inspiring for developing CDT nanomedicines in the future.
引用
收藏
页码:11575 / 11585
页数:11
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