Vitamin B12, homocysteine, and folic acid in patients suffering from bipolar disorders: Relationship with suicide

被引:4
作者
Mangiapane, Paola [1 ]
Carbone, Manuel Glauco [2 ]
Arone, Alessandro [3 ]
Massa, Lucia [3 ]
Palermo, Stefania [3 ]
Flamini, Walter [3 ]
Parra, Elisabetta [3 ]
Morana, Benedetto [1 ]
Morana, Florinda [1 ]
Bertini, Giovanni [1 ]
Marazziti, Donatella [3 ,4 ,5 ]
机构
[1] Casa Cura Morana, Marsala, Italy
[2] Univ Insubria, Dept Med & Surg, Div Psychiat, Varese, Italy
[3] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy
[4] St Camillus Int Univ Hlth & Med Sci UniCamillus, Rome, Italy
[5] Univ Pisa, Dept Clin & Expt Med, Via Roma 57, I-56100 Pisa, Italy
关键词
Vitamin B12; homocysteine; folic acid; bipolar disorders; suicide; COBALAMIN DEFICIENCY; PLASMA HOMOCYSTEINE; DEPRESSIVE SYMPTOMS; RATING-SCALE; OLDER-ADULTS; FOLATE; ASSOCIATION; RISK; BIOAVAILABILITY; BIOMARKER;
D O I
10.1080/15622975.2022.2134589
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
ObjectivesVitamin B12, folic acid, and homocysteine play a key role in 'one-carbon metabolism', involved in different brain processes. Altered levels have been reported in mood disorders (MDs), particularly in major depression (MDD), while the information in bipolar disorders (BDs) is limited. The present study aimed at assessing vitamin B12, homocysteine, and folic acid in 69 bipolar inpatients.MethodsTwenty-seven patients were diagnosed with BDI, 15 BDII, 16 schizoaffective disorders, and 11 MDD, according to DSM-5 criteria. The clinical picture was assessed by the MINI, HRSD, YMRS, and CGI. The blood parameters were measured according to common clinical-chemical methods.ResultsThirty-four patients had significantly lower vitamin B12, and 14 higher homocysteine levels than normative values. Folic acid levels were normal in the majority of the sample. Patients with a family history of suicide showed significantly lower levels of vitamin B12.ConclusionsOur results underline the utility of assessing vitamin B12, homocysteine, and folic acid in patients with BD. Although other studies are necessary, the present findings that lower levels of vitamin B12 seem typical of patients with a family history of suicide independently from the phase of illness suggest that they might constitute a possible predictor of suicide.
引用
收藏
页码:476 / 484
页数:9
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