Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD

被引：10

作者：

Li, Dalin ^{[1
]}

Debbas, Philip ^{[1
]}

Mujukian, Angela ^{[1
]}

Cheng, Susan ^{[2
]}

Braun, Jonathan ^{[1
]}

McGovern, Dermot P. B. ^{[1
]}

Melmed, Gil Y. ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Med, Karsh Div Digest & Liver Dis, Inflammatory Bowel & Immunobiol Res Inst, Los Angeles, CA 90048 USA

[2] Cedars Sinai, Dept Med, Smidt Heart Inst, Los Angeles, CA USA

来源：

INFLAMMATORY BOWEL DISEASES | 2023年 / 29卷 / 06期

关键词：

D O I：

10.1093/ibd/izac174

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Lay Summary The postvaccination symptom profile in patients with IBD is unknown after a third mRNA COVID vaccine dose. In a cohort of 594 subjects with IBD, we demonstrated that 41% experienced any symptoms after a third dose, the vast majority of which were mild and lasted less than 2 days. Symptoms after third dose were less frequently reported than after the second dose. Background The safety of a third dose of SARS-CoV-2 mRNA vaccination in patients with inflammatory bowel disease is unknown. Methods We compared symptoms following a third SARS-CoV-2 mRNA vaccine dose with symptoms after the second dose in IBD. Results The study group included 594 patients (70% female, 58% BNT162b2). Overall, 41% reported symptoms after a third dose. Symptom frequency and severity were lower after the third dose relative to the second dose for every organ system, except for gastrointestinal symptoms which were marginally worse. Conclusion The frequency and severity of symptoms after a third mRNA vaccine dose are generally similar or milder than after a second dose for most organ systems.

引用

页码：883 / 887

页数：5

共 9 条

[1] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[2] Adverse Events After SARS-CoV-2 mRNA Vaccination Among Patients With Inflammatory Bowel Disease [J].

Botwin, Gregory J. ;

Li, Dalin ;

Figueiredo, Jane ;

Cheng, Susan ;

Braun, Jonathan ;

McGovern, Dermot P. B. ;

Melmed, Gil Y. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2021, 116 (08) :1746-1751

[3] COVID-19 Vaccination Intent and Perceptions Among Patients With Inflammatory Bowel Diseases [J].

Dalal, Rahul S. ;

McClure, Emma ;

Marcus, Jenna ;

Winter, Rachel W. ;

Hamilton, Matthew J. ;

Allegretti, Jessica R. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2021, 19 (08) :1730-+

[4] Safety Monitoring of an Additional Dose of COVID-19 Vaccine - United States, August 12-September 19, 2021 [J].

Hause, Anne M. ;

Baggs, James ;

Gee, Julianne ;

Marquez, Paige ;

Myers, Tanya R. ;

Shimabukuro, Tom T. ;

Shay, David K. .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2021, 70 (39) :1379-1384

[5] COVID-19 Vaccine Is Effective in Inflammatory Bowel Disease Patients and Is Not Associated With Disease Exacerbation [J].

Lev-Tzion, Raffi ;

Focht, Gili ;

Lujan, Rona ;

Mendelovici, Adi ;

Friss, Chagit ;

Greenfeld, Shira ;

Kariv, Revital ;

Ben-Tov, Amir ;

Matz, Eran ;

Nevo, Daniel ;

Barak-Corren, Yuval ;

Dotan, Iris ;

Turner, Dan .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2022, 20 (06) :E1263-E1282

[6] Antibody Responses After SARS-CoV-2 mRNA Vaccination in Adults With Inflammatory Bowel Disease [J].

Melmed, Gil Y. ;

Sobhani, Kimia ;

Li, Dalin ;

Prostko, John ;

Figueiredo, Jane ;

Cheng, Susan ;

Braun, Jonathan ;

McGovern, Dermot P. B. .

ANNALS OF INTERNAL MEDICINE, 2021, 174 (12) :1768-+

[7] Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine [J].

Polack, Fernando P. ;

Thomas, Stephen J. ;

Kitchin, Nicholas ;

Absalon, Judith ;

Gurtman, Alejandra ;

Lockhart, Stephen ;

Perez, John L. ;

Perez Marc, Gonzalo ;

Moreira, Edson D. ;

Zerbini, Cristiano ;

Bailey, Ruth ;

Swanson, Kena A. ;

Roychoudhury, Satrajit ;

Koury, Kenneth ;

Li, Ping ;

Kalina, Warren V. ;

Cooper, David ;

Frenck, Robert W., Jr. ;

Hammitt, Laura L. ;

Tureci, Ozlem ;

Nell, Haylene ;

Schaefer, Axel ;

Unal, Serhat ;

Tresnan, Dina B. ;

Mather, Susan ;

Dormitzer, Philip R. ;

Sahin, Ugur ;

Jansen, Kathrin U. ;

Gruber, William C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (27) :2603-2615

[8] Impact of SARS-CoV-2 Vaccination on Inflammatory Bowel Disease Activity and Development of Vaccine-Related Adverse Events: Results From PREVENT-COVID [J].

Weaver, Kimberly N. ;

Zhang, Xian ;

Dai, Xiangfeng ;

Watkins, Runa ;

Adler, Jeremy ;

Dubinsky, Marla C. ;

Kastl, Arthur ;

Bousvaros, Athos ;

Strople, Jennifer A. ;

Cross, Raymond K. ;

Higgins, Peter D. R. ;

Ungaro, Ryan C. ;

Bewtra, Meenakshi ;

Bellaguarda, Emanuelle ;

Farraye, Francis A. ;

Boccieri, Margie E. ;

Firestine, Ann ;

Kappelman, Michael D. ;

Long, Millie D. .

INFLAMMATORY BOWEL DISEASES, 2022, 28 (10) :1497-1505

[9] Risk factors associated with short-term adverse events after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases [J].

Wieske, Luuk ;

Kummer, Laura Y. L. ;

van Dam, Koos P. J. ;

Stalman, Eileen W. ;

van der Kooi, Anneke J. ;

Raaphorst, Joost ;

Lowenberg, Mark ;

Takkenberg, R. Bart ;

Volkers, Adriaan G. ;

D'Haens, Geert R. A. M. ;

Tas, Sander W. ;

Spuls, Phyllis, I ;

Bekkenk, Marcel W. ;

Musters, Annelie H. ;

Post, Nicoline F. ;

Bosma, Angela L. ;

Hilhorst, Marc L. ;

Vegting, Yosta ;

Bemelman, Frederike J. ;

Killestein, Joep ;

van Kempen, Zoe L. E. ;

Voskuyl, Alexandre E. ;

Broens, Bo ;

Sanchez, Agner Parra ;

Wolbink, Gertjan ;

Boekel, Laura ;

Rutgers, Abraham ;

de Leeuw, Karina ;

Horvath, Barbara ;

Verschuuren, Jan J. G. M. ;

Ruiter, Annabel M. ;

van Ouwerkerk, Lotte ;

van der Woude, Diane ;

Allaart, Cornelia F. ;

Teng, Y. K. Onno ;

van Paassen, Pieter ;

Busch, Matthias H. ;

Jallah, B. Papay ;

Brusse, Esther ;

van Doorn, Pieter A. ;

Baars, Adaja E. ;

Hijnen, Dirkjan ;

Schreurs, Corine R. G. ;

van der Pol, W. Ludo ;

Goedee, H. Stephan ;

Steenhuis, Maurice ;

Rispens, Theo ;

Ten Brinke, Anja ;

Verstegen, Niels J. M. ;

Zwinderman, Koos A. H. .

BMC MEDICINE, 2022, 20 (01)

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