Measuring Objective and Subjective Sleep during Lisdexamfetamine Treatment of Acute Methamphetamine Withdrawal: A Feasibility Study

被引:0
作者
Acheson, Liam S. [1 ,2 ,3 ]
Gordon, Christopher [4 ,5 ]
Mcketin, Rebecca [1 ]
Brett, Jonathan [6 ,7 ]
Christmass, Michael [8 ,9 ]
Rodgers, Craig [2 ]
Lintzeris, Nicholas [10 ,11 ,12 ]
Dunlop, Adrian [10 ,13 ,14 ]
Farrell, Michael [1 ]
Shoptaw, Steven [15 ]
Ezard, Nadine [2 ,10 ]
Siefried, Krista J. [1 ,2 ,3 ]
机构
[1] Univ New South Wales, Natl Drug & Alcohol Res Ctr NDARC, Sydney, NSW, Australia
[2] St Vincents Hosp Sydney, Alcohol & Drug Serv, Sydney, NSW, Australia
[3] Univ New South Wales, Natl Ctr Clin Res Emerging Drugs NCCRED, Sydney, NSW, Australia
[4] Univ Sydney, Susan Wakil Sch Nursing & Midwifery, Sydney, NSW, Australia
[5] Univ Sydney, Woolcock Inst Med Res, CIRUS Ctr Sleep & Chronobiol, Sydney, NSW, Australia
[6] St Vincents Hosp Sydney, Clin Pharmacol & Toxicol, Sydney, NSW, Australia
[7] Univ New South Wales, St Vincents Clin Sch, Sydney, NSW, Australia
[8] Next Step Drug & Alcohol Serv, Perth, Australia
[9] Curtin Univ, Natl Drug Res Inst, Perth, WA 6008, Australia
[10] New South Wales Drug & Alcohol Clin Res & Improvem, Sydney, NSW, Australia
[11] Drug & Alcohol Serv, Sydney, NSW, Australia
[12] Univ Sydney, Specialty Addict Med, Sydney, NSW, Australia
[13] Drug & Alcohol Clin Serv, Newcastle, NSW, Australia
[14] Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW, Australia
[15] Univ Calif Los Angeles, Dept Family Med, Los Angeles, CA USA
关键词
Methamphetamine; Sleep; Withdrawal; Measurement; Feasibility; ACTIGRAPHY; POLYSOMNOGRAPHY; DIARY;
D O I
10.1159/000536328
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Introduction: Sleep disturbance is common during methamphetamine (MA) use and withdrawal; however, the feasibility of combined subjective-objective measurement of sleep-wake has not been shown in this population. Actigraphy is a well-established, non-invasive measure of sleep-wake cycles with good concordance with polysomnography. This study aimed to investigate the feasibility and utility of using actigraphy and sleep diaries to investigate sleep during MA withdrawal. Methods: We conducted a feasibility and utility study of actigraphy and sleep diaries during a clinical trial of lisdexamfetamine for MA withdrawal. Participants were inpatients for 7 days, wore an actigraph (Philips Actiwatch 2) and completed a modified Consensus Sleep Diary each morning. Participants were interviewed between days 3-5. Results: Ten participants (mean age 37 years, 90% male) were enrolled. No participant removed the device prematurely. Participants interviewed (n = 8) reported that the actigraph was not difficult or distracting to wear or completion of daily sleep diary onerous. Actigraphic average daily sleep duration over 7 days was 568 min, sleep onset latency 22.4 min, wake after sleep onset (WASO) 75.2 min, and sleep efficiency 83.6%. Sleep diaries underreported daily sleep compared with actigraphy (sleep duration was 56 min (p = 0.008) and WASO 47 min (p < 0.001) less). Overall sleep quality was 4.4 on a nine-point Likert scale within the diary. Conclusions: Continuous actigraphy is feasible to measure sleep-wake in people withdrawing from MA, with low participant burden. We found important differences in self-reported and actigraphic sleep, which need to be explored in more detail.
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收藏
页码:121 / 125
页数:5
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