The effect of protein or amino acid provision on immobilization-induced muscle atrophy in healthy adults: A systematic review and meta-analysis

被引:1
|
作者
Hughes, Alix K. [1 ]
Francis, Thomas [1 ]
Rooney, Jessica [1 ]
Pollock, Ross [1 ]
Witard, Oliver C. [1 ,2 ]
机构
[1] Kings Coll London, Ctr Human & Appl Physiol Sci, London, England
[2] Kings Coll London, Ctr Human & Appl Physiol Sci, London SE1 1UL, England
关键词
muscle atrophy; muscle disuse; muscle mass; nutrition; protein; HUMAN SKELETAL-MUSCLE; BED REST; ANABOLIC RESISTANCE; PROLONGED INACTIVITY; SYNTHESIS RATES; MASS; DISUSE; SUPPLEMENTATION; STRENGTH; HYPERCORTISOLEMIA;
D O I
10.1113/EP090434
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Bed rest and limb immobilization are models of muscle disuse associated with skeletal muscle atrophy and reduced strength. The purpose of this systematic review was to examine the impact of protein or amino acid provision before and/or during a period of muscle disuse on muscle atrophy (primary outcome), strength and muscle protein synthesis (secondary outcomes) following a disuse period. We performed a systematic review of Embase, MEDLINE, Web of Science, PubMed and Clinical Trials in December 2022. Eligible studies were randomized controlled trials that combined a dietary protein or amino acid intervention versus control during an experimental model of disuse (bed rest or unilateral limb immobilization) in healthy individuals aged >= 18 years. Nine articles from eight independent trials were identified and rated for risk of bias by two authors. A meta-analysis of muscle mass data revealed no effect (standardized mean difference: 0.2; 95% confidence interval: -0.18 to 0.57, P = 0.31) of protein/amino acid intervention in preventing disuse-induced muscle atrophy. Although the meta-analysis was not conducted on strength or muscle protein synthesis data, there was insufficient evidence in the reviewed articles to support the use of protein/amino acid provision in mitigating the disuse-induced decline in either outcome measurement. Additional high-quality studies, including the reporting of randomization procedures and blinding procedures and the provision of statistical analysis plans, might be required to determine whether protein or amino acid provision serves as an effective strategy to attenuate muscle atrophy during periods of disuse. What is the topic of this review? This is a systematic review of the potential for protein or amino acid provision as an intervention for mitigating skeletal muscle atrophy associated with periods of disuse. What advances does it highlight? Protein or amino acid provision before or during a period of disuse does not prevent the reductions in skeletal muscle mass, strength or muscle protein synthesis associated with immobilization or bed rest, hence future studies are required to investigate effective nutritional interventions during clinical situations of muscle disuse.
引用
收藏
页码:873 / 888
页数:16
相关论文
共 50 条
  • [31] Physical Effects of Anabolic-androgenic Steroids in Healthy Exercising Adults: A Systematic Review and Meta-analysis
    Andrews, Mary A.
    Magee, Charles D.
    Combest, Travis M.
    Allard, Rhonda J.
    Douglas, Kevin M.
    CURRENT SPORTS MEDICINE REPORTS, 2018, 17 (07) : 232 - 241
  • [32] Inspiratory Muscle Rehabilitation in Critically Ill Adults A Systematic Review and Meta-Analysis
    Vorona, Stefannie
    Sabatini, Umberto
    Al-Maqbali, Sulaiman
    Bertoni, Michele
    Dres, Martin
    Bissett, Bernie
    Van Haren, Frank
    Martin, A. Daniel
    Urrea, Cristian
    Brace, Debbie
    Parotto, Matteo
    Herridge, Margaret S.
    Adhikari, Neill K. J.
    Fan, Eddy
    Melo, Luana T.
    Reid, W. Darlene
    Brochard, Laurent J.
    Ferguson, Niall D.
    Goligher, Ewan C.
    ANNALS OF THE AMERICAN THORACIC SOCIETY, 2018, 15 (06) : 735 - 744
  • [33] The effect of branched-chain amino acid on muscle damage markers and performance following strenuous exercise: a systematic review and meta-analysis
    Doma, Kenji
    Singh, Utkarsh
    Boullosa, Daniel
    Connor, Jonathan Douglas
    APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2021, 46 (11) : 1303 - 1313
  • [34] Effect of respiratory muscle training in asthma: A systematic review and meta-analysis
    Lista-Paz, Ana
    Cousillas, Lucia Bouza
    Jacome, Cristina
    Fregonezi, Guilherme
    Labata-Lezaun, Noe
    Llurda-Almuzara, Luis
    Perez-Bellmunt, Albert
    ANNALS OF PHYSICAL AND REHABILITATION MEDICINE, 2023, 66 (03)
  • [35] Effects of digital-based interventions on the outcomes of the eligibility criteria for sarcopenia in healthy older adults: A systematic review and meta-analysis☆
    Makizako, Hyuma
    Shiratsuchi, Daijo
    Akaida, Shoma
    Tateishi, Mana
    Maeda, Keisuke
    Iijima, Katsuya
    Shimada, Hiroyuki
    Inoue, Tatsuro
    Yamada, Minoru
    Momosaki, Ryo
    Wakabayashi, Hidetaka
    Yamamoto, Koichi
    Arai, Hidenori
    AGEING RESEARCH REVIEWS, 2025, 104
  • [36] Nusinersen in Adults with 5q Spinal Muscular Atrophy: a Systematic Review and Meta-analysis
    Gavriilaki, Maria
    Moschou, Maria
    Papaliagkas, Vasileios
    Notas, Konstantinos
    Chatzikyriakou, Evangelia
    Papagiannopoulos, Sotirios
    Arnaoutoglou, Marianthi
    Kimiskidis, Vasilios K.
    NEUROTHERAPEUTICS, 2022, 19 (02) : 464 - 475
  • [37] Effects of Protein Supplementation in Older Adults Undergoing Resistance Training: A Systematic Review and Meta-Analysis
    Finger, Debora
    Goltz, Fernanda Reistenbach
    Umpierre, Daniel
    Meyer, Elisabeth
    Telles Rosa, Luis Henrique
    Schneider, Claudia Dornelles
    SPORTS MEDICINE, 2015, 45 (02) : 245 - 255
  • [38] Comparison of Muscle Adaptation to Blood Flow-Restricted Versus Traditional Resistance Training in Healthy Adults: A Brief Systematic Review and Meta-analysis
    Mirzayev, Javid
    Levitt, Danielle E.
    STRENGTH AND CONDITIONING JOURNAL, 2025, 47 (02) : 152 - 168
  • [39] Youths Are Less Susceptible to Exercise-Induced Muscle Damage Than Adults: A Systematic Review With Meta-Analysis
    Fernandes, John F. T.
    Hayes, Lawrence D.
    Dingley, Amelia F.
    Moeskops, Sylvia
    Oliver, Jon L.
    Arede, Jorge
    Twist, Craig
    Wilson, Laura J.
    PEDIATRIC EXERCISE SCIENCE, 2024, 36 (03) : 123 - 134
  • [40] Effect of Plyometric Jump Training on Skeletal Muscle Hypertrophy in Healthy Individuals: A Systematic Review With Multilevel Meta-Analysis
    Arntz, F.
    Mkaouer, B.
    Markov, A.
    Schoenfeld, B. J.
    Moran, J.
    Ramirez-Campillo, R.
    Behrens, M.
    Baumert, P.
    Erskine, R. M.
    Hauser, L.
    Chaabene, H.
    FRONTIERS IN PHYSIOLOGY, 2022, 13