Tissue Factor and COVID-19 Associated Thrombosis

被引:4
作者
Mackman, Nigel [1 ,2 ]
机构
[1] Univ N Carolina, UNC Blood Res Ctr, Dept Med, 116 Manning Dr,8004B Mary Ellen Jones Bldg,CB 7035, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, UNC Blood Res Ctr, Dept Med, Chapel Hill, NC USA
基金
美国国家卫生研究院;
关键词
COVID-19; extracellular vesicles; SARS-CoV-2; thromboplastin; thrombosis; BLOOD MONONUCLEAR-CELLS; HEMOSTASIS; RECEPTOR;
D O I
10.1161/ATVBAHA.123.320144
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Microbial infections activate the innate and adaptive immune systems.1 Pathogen-associated molecular patterns produced by microbes, such as double-stranded RNA, are detected by PRRs (pattern-recognition receptors), such as toll-like receptor 3, and this leads to the expression of interferons and cytokines.(1,2)
引用
收藏
页码:523 / 529
页数:7
相关论文
共 38 条
  • [31] Presence of procoagulant peripheral blood mononuclear cells in severe COVID-19 patients relate to ventilation perfusion mismatch and precede pulmonary embolism
    Raadsen, M.
    Langerak, T.
    Du Toit, J.
    Kruip, M. J. H. A.
    Mersha, D. Aynekulu
    De Maat, M. P. M.
    Vermin, B.
    Van den Akker, J. P. C.
    Schmitz, K. S.
    Bakhtiari, K.
    Meijers, J. C. M.
    van Gorp, E. C. M.
    Short, K. R.
    Haagmans, B.
    de Vries, R. D.
    Gommers, D. A. M. P. J.
    Endeman, H.
    Goeijenbier, M.
    [J]. JOURNAL OF CRITICAL CARE, 2024, 79
  • [32] A novel c5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways
    Ritis, Konstantinos
    Doumas, Michael
    Mastellos, Dimitrios
    Micheli, Anastasia
    Giaglis, Stavros
    Magotti, Paola
    Rafail, Stavros
    Kartalis, Georgios
    Sideras, Paschalis
    Lambris, John D.
    [J]. JOURNAL OF IMMUNOLOGY, 2006, 177 (07) : 4794 - 4802
  • [33] Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality-Brief Report
    Rosell, Axel
    Havervall, Sebastian
    von Meijenfeldt, Fien
    Hisada, Yohei
    Aguilera, Katherina
    Grover, Steven P.
    Lisman, Ton
    Mackman, Nigel
    Thalin, Charlotte
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2021, 41 (02) : 878 - 882
  • [34] Monocyte Tissue Factor Expression: Lipopolysaccharide Induction and Roles in Pathological Activation of Coagulation
    Sachetto, Ana T. A.
    Mackman, Nigel
    [J]. THROMBOSIS AND HAEMOSTASIS, 2023, 123 (11) : 1017 - 1033
  • [35] Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis
    Skendros, Panagiotis
    Mitsios, Alexandros
    Chrysanthopoulou, Akrivi
    Mastellos, Dimitrios C.
    Metallidis, Simeon
    Rafailidis, Petros
    Ntinopoulou, Maria
    Sertaridou, Eleni
    Tsironidou, Victoria
    Tsigalou, Christina
    Tektonidou, Maria
    Konstantinidis, Theocharis
    Papagoras, Charalampos
    Mitroulis, Ioannis
    Germanidis, Georgios
    Lambris, John D.
    Ritis, Konstantinos
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (11) : 6151 - 6157
  • [36] Thrombosis in hospitalized patients with viral respiratory infections versus COVID-19
    Smilowitz, Nathaniel R.
    Subashchandran, Varun
    Yuriditsky, Eugene
    Horowitz, James M.
    Reynolds, Harmony R.
    Hochman, Judith S.
    Berger, Jeffrey S.
    [J]. AMERICAN HEART JOURNAL, 2021, 231 : 93 - 95
  • [37] Tissue factor upregulation is associated with SARS-CoV-2 in the lungs of COVID-19 patients
    Subrahmanian, Sandeep
    Borczuk, Alain
    Salvatore, Steven
    Fung, Kar-Ming
    Merrill, Joan T.
    Laurence, Jeffrey
    Ahamed, Jasimuddin
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2021, 19 (09) : 2268 - 2274
  • [38] Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients
    Xiong, Yong
    Liu, Yuan
    Cao, Liu
    Wang, Dehe
    Guo, Ming
    Jiang, Ao
    Guo, Dong
    Hu, Wenjia
    Yang, Jiayi
    Tang, Zhidong
    Wu, Honglong
    Lin, Yongquan
    Zhang, Meiyuan
    Zhang, Qi
    Shi, Mang
    Liu, Yingle
    Zhou, Yu
    Lan, Ke
    Chen, Yu
    [J]. EMERGING MICROBES & INFECTIONS, 2020, 9 (01) : 761 - 770