Particle circulation and coating in a Wurster fluidized bed under different geometries

被引:2
作者
Guo, Jinnan [1 ]
Liu, Daoyin [1 ]
Ma, Jiliang [1 ]
Liang, Cai [1 ]
Chen, Xiaoping [1 ]
机构
[1] Southeast Univ, Key Lab Energy Thermal Convers & Control, Minist Educ, Nanjing 210096, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
Wurster fluidized bed; Particle coating; Residence time distribution; Particle uniformity; RESIDENCE TIME DISTRIBUTIONS; NEAR-INFRARED SPECTROSCOPY; GAS-SOLID FLOW; CFD-DEM; SPRAY ZONE; GRANULATION; UNIFORMITY; TOMOGRAPHY; SIMULATION; THICKNESS;
D O I
10.1016/j.powtec.2023.119223
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
The performance of particle coating is essentially determined by the morphology and uniformity of coating shells, which significantly depend on particle circulation. In this study, the geometry of a Wurster fluidized bed is changed by regulating particle circulation port size and nozzle position, and their effects on particle circulation and coating properties are investigated by combining coating experiments and CFD - Discrete Element Model (DEM). By increasing the circulation port size, the particle circulation rate first increases then decreases slightly, accordingly, the uniformity of particle circulation increases then decreases, while the shell porosity decreases. By increasing the nozzle height, the particle circulation rate decreases slightly, accordingly, the uniformity of particle circulation increases then decreases, while the shell porosity decreases. At extremes with a too small circulation port size or too high nozzle position, particle residence and cycle time distribution are broader, and an obvious nonuniformity of particle growth is observed.
引用
收藏
页数:14
相关论文
共 33 条
[1]   Experimental investigation and correlation of the Bodenstein number in horizontal fluidized beds with internal baffles [J].
Bachmann, P. ;
Bueck, A. ;
Tsotsas, E. .
POWDER TECHNOLOGY, 2017, 308 :378-387
[2]   Computational Fluid Dynamics-Discrete Element Method Modeling of an Industrial-Scale Wurster Coater [J].
Boehling, Peter ;
Khinast, Johannes G. ;
Jajcevic, Dalibor ;
Davies, Conrad ;
Carmody, Alan ;
Doshi, Pankaj ;
Ende, Mary T. Am ;
Sarkar, Avik .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 108 (01) :538-550
[3]   Experimental spray zone characterization in top-spray fluidized bed granulation [J].
Boerner, Matthias ;
Hagemeier, Thomas ;
Ganzer, Gunnar ;
Peglow, Mirko ;
Tsotsas, Evangelos .
CHEMICAL ENGINEERING SCIENCE, 2014, 116 :317-330
[4]   Particle Residence Times in Fluidized Bed Granulation Equipments [J].
Boerner, Matthias ;
Peglow, Mirko ;
Tsotsas, Evangelos .
CHEMICAL ENGINEERING & TECHNOLOGY, 2011, 34 (07) :1116-1122
[5]   In-line analysis of a fluid bed pellet coating process using a combination of near infrared and Raman spectroscopy [J].
Bogomolov, Andrey ;
Engler, Maximiliane ;
Melichar, Michael ;
Wigmore, Anthony .
JOURNAL OF CHEMOMETRICS, 2010, 24 (7-8) :544-557
[6]   A review on key aspects of wet granulation process for continuous pharmaceutical manufacturing of solid dosage oral formulations [J].
Chen, Ping ;
Ansari, Mohammad Javed ;
Bokov, Dmitry ;
Suksatan, Wanich ;
Rahman, Md Lutfor ;
Sarjadi, Mohd Sani .
ARABIAN JOURNAL OF CHEMISTRY, 2022, 15 (02)
[7]  
Findlay WP, 2005, J PHARM SCI-US, V94, P604
[8]   Influence of granule porosity during fluidized bed spray granulation [J].
Hoffmann, Torsten ;
Rieck, Christian ;
Bueck, Andreas ;
Peglow, Mirko ;
Tsotsas, Evangelos .
NEW PARADIGM OF PARTICLE SCIENCE AND TECHNOLOGY, PROCEEDINGS OF THE 7TH WORLD CONGRESS ON PARTICLE TECHNOLOGY, 2015, 102 :458-467
[9]   A study on the applicability of in-line measurements in the monitoring of the pellet coating process [J].
Hudovornik, Grega ;
Korasa, Klemen ;
Vrecer, Franc .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 75 :160-168
[10]   Modeling of inter- and intra-particle coating uniformity in a Wurster fluidized bed by a coupled CFD-DEM-Monte Carlo approach [J].
Jiang, Zhaochen ;
Rieck, Christian ;
Bueck, Andreas ;
Tsotsas, Evangelos .
CHEMICAL ENGINEERING SCIENCE, 2020, 211