Actinobacillus pleuropneumoniae, surface proteins and virulence: a review

被引:6
作者
Soto Perezchica, Maria M. [1 ]
Guerrero Barrera, Alma L. [1 ]
Avelar Gonzalez, Francisco J. [2 ]
Quezada Tristan, Teodulo [3 ]
Macias Marin, Osvaldo [1 ]
机构
[1] Univ Autonoma Aguascalientes, Ctr Ciencias Basicas, Dept Morfol, Lab Biol Celular & Tisular, Aguascalientes, Mexico
[2] Univ Autonoma Aguascalientes, Ctr Ciencias Basicas, Dept Fisiol & Farmacol, Lab Estudios Ambientales, Aguascalientes, Mexico
[3] Univ Autonoma Aguascalientes, Ctr Ciencias Agr, Dept Ciencias Vet, Aguascalientes, Mexico
关键词
Actinobacillus pleuropneumoniae; bacterial envelope; membrane proteins; proteome; vaccine; biofilm; OUTER-MEMBRANE PROTEIN; GRAM-NEGATIVE BACTERIA; BIOFILM FORMATION; ESCHERICHIA-COLI; AUTOTRANSPORTER PROTEIN; MOONLIGHTING PROTEINS; MOLECULAR-CLONING; STRESS TOLERANCE; MULTIPLEX PCR; OMLA GENE;
D O I
10.3389/fvets.2023.1276712
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Actinobacillus pleuropneumoniae (App) is a globally distributed Gram-negative bacterium that produces porcine pleuropneumonia. This highly contagious disease produces high morbidity and mortality in the swine industry. However, no effective vaccine exists to prevent it. The infection caused by App provokes characteristic lesions, such as edema, inflammation, hemorrhage, and necrosis, that involve different virulence factors. The colonization and invasion of host surfaces involved structures and proteins such as outer membrane vesicles (OMVs), pili, flagella, adhesins, outer membrane proteins (OMPs), also participates proteases, autotransporters, and lipoproteins. The recent findings on surface structures and proteins described in this review highlight them as potential immunogens for vaccine development.
引用
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页数:15
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