Challenges and progress of neurodrug: bioactivities, production and delivery strategies of nerve growth factor protein

被引:3
作者
Zhou, Nan [1 ]
Gu, Tingwei [1 ]
Xu, Yang [1 ]
Liu, Yuda [1 ]
Peng, Lihua [1 ,2 ,3 ]
机构
[1] Zhejiang Univ, Coll Pharmaceut Sci, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China
[2] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
[3] Zhejiang Univ, Jinhua Inst, Jinhua 321299, Zhejiang, Peoples R China
关键词
Nerve growth factor; Pharmacological effects; Synthesis methods; Delivery strategies; MESENCHYMAL STEM-CELLS; IN-VITRO; RECOMBINANT PROTEINS; NEUROTROPHIC FACTOR; GENE DELIVERY; INSECT CELLS; BLOOD-BRAIN; EXPRESSION; NGF; PURIFICATION;
D O I
10.1186/s13036-023-00392-2
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Nerve growth factor (NGF) is a vital cytokine that plays a crucial role in the development and regeneration of the nervous system. It has been extensively studied for its potential therapeutic applications in various neural diseases. However, as a protein drug, limited natural source seriously hinders its translation and clinical applications. Conventional extraction of NGF from mouse submandibular glands has a very high cost and potentially induces immunogenicity; total synthesis and semi-synthesis methods are alternatives, but have difficulty in obtaining correct protein structure; gene engineering of plant cells is thought to be non-immunogenic, bioactive and economical. Meanwhile, large molecular weight, high polarity, and negative electrical charge make it difficult for NGF to cross the blood brain barrier to reach therapeutic targets. Current delivery strategies mainly depend on the adenovirus and cell biodelivery, but the safety and efficacy remain to be improved. New materials are widely investigated for the controllable, safe and precise delivery of NGF. This review illustrates physiological and therapeutic effects of NGF for various diseases. Moreover, new progress in production and delivery technologies for NGF are summarized. Bottlenecks encountered in the development of NGF as therapeutics are also discussed with the countermeasures proposed.
引用
收藏
页数:17
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