Mesenchymal Stem Cells Therapy for COVID-19: From Basic Research to Clinical Trial

被引：1

作者：

Tao, Ya-Chao ^{[1
,2
]}

Chen, En-Qiang ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, Ctr Infect Dis, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, Div Infect Dis, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2024年 / 19卷 / 01期

关键词：

Coronavirus disease 2019; mesenchymal stem cells; immunomodulation; inflammation; clinical trial; severe acute respiratory syndrome coronavirus 2;

D O I：

10.2174/1574888X18666230118122256

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The novel pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a serious challenge for human health. In severe cases, patients suffer from acute respiratory distress syndrome even organ failure, usually owing to the dysregulated immune response and widespread inflammation. Considering that there is no known cure for COVID-19 despite the increased morbidity and mortality rate of COVID-19, modalities targeting immunity and inflammation may be promising therapeutics against COVID-19. Mesenchymal stem cells (MSCs) possessing immunomodulatory, anti-inflammatory, anti-apoptotic, and antiviral properties, can be of potential benefit to a subset of severe and critically ill patients with COVID-19. In the present study, we described the underlying mechanisms of MSCs therapy and provided a thorough research study on the recent clinical trials of MSCs for SARS-CoV-2 infection.

引用

页码：55 / 62

页数：8

共 52 条

[41] Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept study [J].

Sanchez-Guijo, Fermin ;

Garcia-Arranz, Mariano ;

Lopez-Parra, Miriam ;

Monedero, Pablo ;

Mata-Martinez, Carmen ;

Santos, Arnoldo ;

Sagredo, Victor ;

Alvarez-Avello, Jose-Manuel ;

Guerrero, Jose Eugenio ;

Perez-Calvo, Cesar ;

Sanchez-Hernandez, Miguel-Vicente ;

Del-Pozo, Jose Luis ;

Andreu, Enrique J. ;

Fernandez-Santos, Maria-Eugenia ;

Soria-Juan, Barbara ;

Hernandez-Blasco, Luis M. ;

Andreu, Etelvina ;

Sempere, Jose M. ;

Zapata, Agustin G. ;

Moraleda, Jose M. ;

Soria, Bernat ;

Fernandez-Aviles, Francisco ;

Garcia-Olmo, Damian ;

Prosper, Felipe .

ECLINICALMEDICINE, 2020, 25

[42] Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial [J].

Shi, Lei ;

Huang, Hai ;

Lu, Xuechun ;

Yan, Xiaoyan ;

Jiang, Xiaojing ;

Xu, Ruonan ;

Wang, Siyu ;

Zhang, Chao ;

Yuan, Xin ;

Xu, Zhe ;

Huang, Lei ;

Fu, Jun-Liang ;

Li, Yuanyuan ;

Zhang, Yu ;

Yao, Wei-Qi ;

Liu, Tianyi ;

Song, Jinwen ;

Sun, Liangliang ;

Yang, Fan ;

Zhang, Xin ;

Zhang, Bo ;

Shi, Ming ;

Meng, Fanping ;

Song, Yanning ;

Yu, Yongpei ;

Wen, Jiqiu ;

Li, Qi ;

Mao, Qing ;

Maeurer, Markus ;

Zumla, Alimuddin ;

Yao, Chen ;

Xie, Wei-Fen ;

Wang, Fu-Sheng .

SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 6 (01)

[43] Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells [J].

Shu, Lei ;

Niu, Changming ;

Li, Ruyou ;

Huang, Tingrong ;

Wang, Yan ;

Huang, Mao ;

Ji, Ningfei ;

Zheng, You ;

Chen, Xiaolin ;

Shi, Lei ;

Wu, Mingjing ;

Deng, Kaili ;

Wei, Jing ;

Wang, Xueli ;

Cao, Yang ;

Yan, Jiaxin ;

Feng, Ganzhu .

STEM CELL RESEARCH & THERAPY, 2020, 11 (01)

[44] Interferon-stimulated gene 15 (ISG15) restricts Zika virus replication in primary human corneal epithelial cells [J].

Singh, Pawan Kumar ;

Singh, Sneha ;

Farr, Dustin ;

Kumar, Ashok .

OCULAR SURFACE, 2019, 17 (03) :551-559

[45] The trinity of COVID-19: immunity, inflammation and intervention [J].

Tay, Matthew Zirui ;

Poh, Chek Meng ;

Renia, Laurent ;

MacAry, Paul A. ;

Ng, Lisa F. P. .

NATURE REVIEWS IMMUNOLOGY, 2020, 20 (06) :363-374

[46] Intrinsic Immunity Shapes Viral Resistance of Stem Cells [J].

Wu, Xianfang ;

Viet Loan Dao Thi ;

Huang, Yumin ;

Billerbeck, Eva ;

Saha, Debjani ;

Hoffmann, Hans-Heinrich ;

Wang, Yaomei ;

Silva, Luis A. Vale ;

Sarbanes, Stephanie ;

Sun, Tony ;

Andrus, Linda ;

Yu, Yingpu ;

Quirk, Corrine ;

Li, Melody ;

MacDonald, Margaret R. ;

Schneider, William M. ;

An, Xiuli ;

Rosenberg, Brad R. ;

Rice, Charles M. .

CELL, 2018, 172 (03) :423-+

[47] Umbilical Cord-derived Mesenchymal Stem Cells with Surfactant Protein B Alleviates Inflammatory Response in Acute Respiratory Distress Syndrome by Regulating Macrophage Polarization [J].

Xu, Hongtao ;

Nie, Guoming ;

Yin, Taiyong ;

Shao, Cui ;

Ding, Dongsheng ;

Zou, Minshu .

BALKAN MEDICAL JOURNAL, 2022, 39 (02) :130-139

[48] Evaluation of the safety and efficacy of using human menstrual blood-derived mesenchymal stromal cells in treating severe and critically ill COVID-19 patients: An exploratory clinical trial [J].

Xu, Xiaowei ;

Jiang, Wanli ;

Chen, Lijun ;

Xu, Zhenyu ;

Zhang, Qiang ;

Zhu, Mengfei ;

Ye, Peng ;

Li, Hang ;

Yu, Liang ;

Zhou, Xiaoyang ;

Zhou, Chenliang ;

Chen, Xiaobei ;

Zheng, Xiaoqin ;

Xu, Kaijin ;

Cai, Hongliu ;

Zheng, Shufa ;

Jiang, Wubian ;

Wu, Xiaojun ;

Li, Dong ;

Chen, Lu ;

Luo, Qingqing ;

Wang, Yingyan ;

Qu, Jingjing ;

Li, Yifei ;

Zheng, Wendi ;

Jiang, Yingan ;

Tang, Lingling ;

Xiang, Charlie ;

Li, Lanjuan .

CLINICAL AND TRANSLATIONAL MEDICINE, 2021, 11 (02)

[49] Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19 [J].

Yang, Yang ;

Shen, Chenguang ;

Li, Jinxiu ;

Yuan, Jing ;

Wei, Jinli ;

Huang, Fengmin ;

Wang, Fuxiang ;

Li, Guobao ;

Li, Yanjie ;

Xing, Li ;

Peng, Ling ;

Yang, Minghui ;

Cao, Mengli ;

Zheng, Haixia ;

Wu, Weibo ;

Zou, Rongrong ;

Li, Delin ;

Xu, Zhixiang ;

Wang, Haiyan ;

Zhang, Mingxia ;

Zhang, Zheng ;

Gao, George F. ;

Jiang, Chengyu ;

Liu, Lei ;

Liu, Yingxia .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2020, 146 (01) :119-+

[50] The Vascular Endothelial Growth Factors-Expressing Character of Mesenchymal Stem Cells Plays a Positive Role in Treatment of Acute Lung Injury In Vivo [J].

Yang, Yi ;

Hu, Shuling ;

Xu, Xiuping ;

Li, Jinze ;

Liu, Airan ;

Han, Jibin ;

Liu, Songqiao ;

Liu, Ling ;

Qiu, Haibo .

MEDIATORS OF INFLAMMATION, 2016, 2016

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