Recent advances in curcumin-based nanoformulations in diabetes

被引:7
作者
Ataei, Mahshid [1 ,2 ]
Gumpricht, Eric [3 ]
Kesharwani, Prashant [4 ,5 ,8 ]
Jamialahmadi, Tannaz [6 ]
Sahebkar, Amirhossein [6 ,7 ]
机构
[1] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran
[2] Univ Tehran Med Sci, Inst Pharmaceut Sci TIPS, Pharmaceut Sci Res Ctr, Sch Pharm & Toxicol & Dis Grp,Dept Toxicol & Pharm, Tehran, Iran
[3] Isagenix Int LLC, Gilbert, AZ USA
[4] Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi, India
[5] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Dent Coll, Dept Pharmacol, Chennai, India
[6] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran
[7] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran
[8] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi, India
关键词
Nanocurcumin; diabetes; polymer; lipid carrier; nanohydrogels; drug delivery; drug targeting; controlled drug delivery; targeted drug delivery; NANO-CURCUMIN; DOUBLE-BLIND; RAT MODEL; IN-VITRO; NANOPARTICLES; BIOAVAILABILITY; ENCAPSULATION; RESISTANCE; CHITOSAN;
D O I
10.1080/1061186X.2023.2229961
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Diabetes is predicted to affect 700 million people by the year 2045. Despite the potential benefits for diabetics, curcumin's low bioavailability significantly reduces its utility. However, newer formulation methods of decreasing particle size, such as through nanotechnological advances, may improve curcumin's bioavailability and cell-absorption properties. Various curcumin nanoformulations such as nanofibers, nanoparticles-like nanostructured lipid carriers (NLCs), Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS) and nanohydrogels have been evaluated. These studies reported increased bioavailability of nanoformulated curcumin compared to free curcumin. Here, we provide a detailed review of the antidiabetic effects of nanocurcumin compounds and subsequent effects on diabetic complications. Overall, various nanocurcumin formulations highly increase curcumin water-solubility and bioavailability and these safe formulations can positively affect managing some diabetes-related manifestations and complications. Moreover, nanocurcumin efficacy in various diabetes complications is discussed. These complications included inflammation, neuropathy, depression, anxiety, keratopathy, cataract, cardiomyopathy, myocardial infarction (MI), nephropathy, erectile dysfunction and diabetic wound. Moreover, several nanocurcumin formulations improved wound healing in the diabetic. However, few studies have been performed in humans, and most results have been reported from cellular and animal studies. Therefore, more human studies are needed to prove the antidiabetic effects of nanocurcumin.
引用
收藏
页码:671 / 684
页数:14
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