Chaperone-Mediated Autophagy: A Potential Target for Metabolic Diseases

被引：8

作者：

Yang, Ming ^{[1
,2
]}

Luo, Shilu ^{[2
]}

Chen, Wei ^{[2
]}

Zhao, Li ^{[3
]}

Wang, Xi ^{[1
,4
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Nutr, Changsha 410008, Hunan, Peoples R China

[2] Cent South Univ, Dept Nephrol, Xiangya Hosp 2, Changsha, Peoples R China

[3] Kunming Med Univ, Dept Reprod & Genet, Affiliated Hosp 1, Kunming, Peoples R China

[4] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2023年 / 30卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Chaperone-mediated autophagy (CMA); metabolic diseases; autophagy; diabetic nephropathy (DN); LAMP2A; HSC70; PEPTIDE SEQUENCES; LIVER; DEGRADATION; PROTEINS; MACROAUTOPHAGY; MODULATION; MACHINERY; MUSCLE; SIRT3;

D O I：

10.2174/0929867329666220811141955

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is the process by which cells selectively remove damaged organelles or proteins. Chaperone-mediated autophagy (CMA) is a type of autophagy that degrades proteins containing the KFERQ pentapeptide in cells. CMA can degrade damaged or excess proteins and therefore plays an important role in maintaining protein balance in cells. CMA can also play a regulatory role by degrading key proteins in life activities, such as lipid and glucose metabolism. This review introduces the CMA process and describes the current commonly used CMA detection methods. In addition, we describe the role of CMA in glucose and lipid metabolism. Finally, we summarize the current role of CMA in metabolic diseases such as diabetic nephropathy (DN), alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) and discuss the role of CMA as a potential therapeutic target for metabolic diseases.

引用

页码：1887 / 1899

页数：13

共 50 条

[1] Deficient Chaperone-Mediated Autophagy in Liver Leads to Metabolic Dysregulation
Schneider, Jaime L.
Suh, Yousin
Cuervo, Ana Maria
CELL METABOLISM, 2014, 20 (03) : 417 - 432
[2] The Complex Role of Chaperone-Mediated Autophagy in Cancer Diseases
Liu, Jing
Wang, Lijuan
He, Hua
Liu, Yueying
Jiang, Yiqun
Yang, Jinfeng
BIOMEDICINES, 2023, 11 (07)
[3] Chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapy
Liu, Yi
Tan, Lan
Tan, Meng-Shan
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2023, 478 (10) : 2173 - 2190
[4] Chaperone-Mediated Autophagy in Neurodegenerative Diseases: Molecular Mechanisms and Pharmacological Opportunities
Wang, Yi-Ting
Lu, Jia-Hong
CELLS, 2022, 11 (14)
[5] Targeting chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapeutic potential
Wu, Jin
Xu, Wan
Su, Ying
Wang, Guang-hui
Ma, Jing-jing
ACTA PHARMACOLOGICA SINICA, 2024, : 816 - 828
[6] Chaperone-mediated autophagy at a glance
Kaushik, Susmita
Bandyopadhyay, Urmi
Sridhar, Sunandini
Kiffin, Roberta
Martinez-Vicente, Marta
Kon, Maria
Orenstein, Samantha J.
Wong, Esther
Cuervo, Ana Maria
JOURNAL OF CELL SCIENCE, 2011, 124 (04) : 495 - 499
[7] Chaperone-Mediated Autophagy
Yang, Qian
Wang, Ronglin
Zhu, Lin
AUTOPHAGY: BIOLOGY AND DISEASES: BASIC SCIENCE, 2019, 1206 : 435 - 452
[8] Chaperone-mediated autophagy
Dice, J. Fred
AUTOPHAGY, 2007, 3 (04) : 295 - 299
[9] Chaperone-mediated autophagy as a therapeutic target for Parkinson disease
Campbell, Philip
Morris, Huw
Schapira, Anthony
EXPERT OPINION ON THERAPEUTIC TARGETS, 2018, 22 (10) : 823 - 832
[10] Reciprocal Regulation of Chaperone-Mediated Autophagy/Microautophagy and Exosome Release
Oshima, Mutsumi
Seki, Takahiro
Kurauchi, Yuki
Hisatsune, Akinori
Katsuki, Hiroshi
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2019, 42 (08) : 1394 - 1401

← 1 2 3 4 5 →