Natural products modulate cell apoptosis: a promising way for treating endometrial cancer

被引：8

作者：

Zhou, Xin ^{[1
]}

Zeng, Yiwei ^{[1
]}

Zheng, Runchen ^{[2
]}

Wang, Yuemei ^{[1
]}

Li, Tao ^{[1
]}

Song, Shanshan ^{[2
]}

Zhang, Su ^{[1
]}

Huang, Jinzhu ^{[3
,4
]}

Ren, Yulan ^{[2
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Chengdu, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Sch Chinese Class, Chengdu, Peoples R China

[3] Chengdu Univ Tradit Chinese Med, Sch Nursing, Chengdu, Peoples R China

[4] Chengdu Univ Tradit Chinese Med, Sch Clin Med, Dept Gynecol, Chengdu, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

natural products; endometrial cancer; apoptosis; signal pathway; anti-cancer effects; ENDOPLASMIC-RETICULUM STRESS; CYCLE ARREST; PI3K/AKT/MTOR PATHWAY; SIGNALING PATHWAYS; GROWTH-INHIBITION; PROLIFERATION; MANAGEMENT; INDUCTION; EXPRESSION; THERAPY;

D O I：

10.3389/fphar.2023.1209412

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Endometrial cancer (EC) is a prevalent epithelial malignancy in the uterine corpus's endometrium and myometrium. Regulating apoptosis of endometrial cancer cells has been a promising approach for treating EC. Recent in-vitro and in-vivo studies show that numerous extracts and monomers from natural products have pro-apoptotic properties in EC. Therefore, we have reviewed the current studies regarding natural products in modulating the apoptosis of EC cells and summarized their potential mechanisms. The potential signaling pathways include the mitochondria-dependent apoptotic pathway, endoplasmic reticulum stress (ERS) mediated apoptotic pathway, the mitogen-activated protein kinase (MAPK) mediated apoptotic pathway, NF-?B-mediated apoptotic pathway, PI3K/AKT/mTOR mediated apoptotic pathway, the p21-mediated apoptotic pathway, and other reported pathways. This review focuses on the importance of natural products in treating EC and provides a foundation for developing natural products-based anti-EC agents.

引用

页数：20

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