Baricitinib Treatment of Coronavirus Disease 2019 Is Associated With a Reduction in Secondary Infections

被引：5

作者：

Sweeney, Daniel A. ^{[1
]}

Tuyishimire, Bonifride ^{[2
]}

Ahuja, Neera ^{[3
]}

Beigel, John H. ^{[4
]}

Beresnev, Tatiana ^{[4
]}

Cantos, Valeria D. ^{[5
]}

Castro, Jose G. ^{[6
]}

Cohen, Stuart H. ^{[7
]}

Cross, Kaitlyn ^{[2
]}

Dodd, Lori E. ^{[4
]}

Erdmann, Nathan ^{[8
]}

Fung, Monica ^{[9
]}

Ghazaryan, Varduhi ^{[4
]}

George, Sarah L. ^{[10
,11
]}

Grimes, Kevin A. ^{[12
]}

Hynes, Noreen A. ^{[13
]}

Julian, Kathleen G. ^{[14
]}

Kandiah, Sheetal ^{[5
]}

Kim, Hannah Jang ^{[15
,16
]}

Levine, Corri B. ^{[17
]}

Lindholm, David A. ^{[18
,19
]}

Lye, David C. ^{[20
,21
,22
,23
]}

Maves, Ryan C. ^{[24
,25
]}

Oh, Myoung-don ^{[26
]}

Paules, Catharine ^{[14
]}

Rapaka, Rekha R. ^{[27
]}

Short, Willam R. ^{[28
]}

Tomashek, Kay M. ^{[4
]}

Wolfe, Cameron R. ^{[29
]}

Kalil, Andre C. ^{[30
]}

机构：

[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[2] Emmes Co LLC, Rockville, MD USA

[3] Stanford Univ, Dept Med, Palo Alto, CA USA

[4] NIAID, NIH, Bethesda, MD USA

[5] Emory Univ, Dept Med, Atlanta, GA USA

[6] Univ Miami, Dept Med, Miami, FL USA

[7] Univ Calif Davis, Dept Internal Med, Sacramento, CA USA

[8] Univ Alabama Birmingham UAB, Dept Med, Birmingham, AL USA

[9] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[10] St Louis Univ, Dept Med, St Louis, MO USA

[11] St Louis VA Med Ctr, St Louis, MO USA

[12] Houston Methodist, Dept Med, Houston, TX USA

[13] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD USA

[14] Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Hershey, PA USA

[15] Univ Calif San Francisco, Community Hlth Syst Dept, San Francisco, CA USA

[16] Kaiser Permanente Natl Patient Care Serv, Dept Nursing, Oakland, CA USA

[17] Univ Texas Med Branch, Dept Internal Med Galveston, Galveston, TX USA

[18] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD USA

[19] Brooke Army Med Ctr, Dept Med, Joint Base San Antonio Ft, TX USA

[20] Natl Ctr Infect Dis, Singapore, Singapore

[21] Tan Tock Seng Hosp, Dept Infect Dis, Singapore, Singapore

[22] Lee Kong Chian Sch Med, Singapore, Singapore

[23] Yong Loo Lin Sch Med, Singapore, Singapore

[24] Wake Forest Univ, Dept Internal Med, Winston Salem, NC USA

[25] Wake Forest Univ, Dept Anesthesiol, Winston Salem, NC USA

[26] Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea

[27] Univ Maryland, Ctr Vaccine Dev & Global Hlth, Dept Med, Sch Med, Baltimore, MD USA

[28] Univ Penn, Dept Med, Philadelphia, PA USA

[29] Duke Univ, Dept Med, Durham, NC USA

[30] Univ Nebraska Med Ctr, Dept Internal Med, Omaha, NE 68198 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2023年 / 10卷 / 05期

关键词：

baricitinib; COVID-19; secondary infections;

D O I：

10.1093/ofid/ofad205

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We performed a secondary analysis of the National Institutes of Health-sponsored Adaptive COVID-19 Treatment Trial (ACTT-2) randomized controlled trial and found that baricitinib was associated with a 50% reduction in secondary infections after controlling for baseline and postrandomization patient characteristics. This finding provides a novel mechanism of benefit for baricitinib and supports the safety profile of this immunomodulator for the treatment of coronavirus disease 2019.

引用

页数：4

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