NMR resonance assignment of a fibroblast growth factor 8 splicing isoform b

被引：1

作者：

Hargittay, Bruno ^{[1
]}

Mineev, Konstantin S. ^{[1
]}

Richter, Christian ^{[1
]}

Sreeramulu, Sridhar ^{[1
]}

Jonker, Hendrik R. A. ^{[1
]}

Saxena, Krishna ^{[1
,2
]}

Schwalbe, Harald ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, Ctr Biomol Magnet Resonance BMRZ, Max Von Laue Str 7, D-60438 Frankfurt Main, Germany

[2] Goethe Univ Frankfurt, Struct Genom Consortium, Max Von Laue Str 7, D-60438 Frankfurt Main, Germany

来源：

BIOMOLECULAR NMR ASSIGNMENTS | 2023年 / 17卷 / 01期

关键词：

Fibroblast growth factor; FGF8b; FGF8; FGF; Structure; Dynamics; Motions; FGFR; Fibroblast growth factor receptor; SECONDARY STRUCTURE; FACTOR RECEPTOR; SMALL-MOLECULE; FGF8; BINDING; SEQUENCE; HEPARIN;

D O I：

10.1007/s12104-023-10132-8

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The splicing isoform b of human fibroblast growth factor 8 (FGF8b) is an important regulator of brain embryonic development. Here, we report the almost complete NMR chemical shift assignment of the backbone and aliphatic side chains of FGF8b. Obtained chemical shifts are in good agreement with the previously reported X-ray data, excluding the N-terminal gN helix, which apparently forms only in complex with the receptor. The reported data provide an NMR starting point for the investigation of FGF8b interaction with its receptors and with potential drugs or inhibitors.

引用

页码：135 / 142

页数：8

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