Role of ACSL5 in fatty acid metabolism

被引：26
作者：
Luo, Qin [1 ,2 ]
Das, Avash [3 ]
Oldoni, Federico [3 ]
Wu, Panyun [1 ,2 ,3 ]
Wang, Jiangang [4 ]
Luo, Fei [1 ,2 ]
Fang, Zhenfei [1 ,2 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Cardiovasc Med, Changsha 410011, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp 2, Res Inst Blood Lipid & Atherosclerosis, Changsha 410011, Hunan, Peoples R China
[3] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Genet, Dallas, TX USA
[4] Cent South Univ, Xiangya Hosp 3, Dept Hlth Management, Changsha 410013, Hunan, Peoples R China
来源：
HELIYON | 2023年 / 9卷 / 02期
基金：
中国国家自然科学基金;
关键词：
ACSL5; Lipid metabolism; Insulin resistance; Fatty acid; Energy homeostasis; ACYL-COA SYNTHETASE; INSULIN-RESISTANCE; SKELETAL-MUSCLE; GENE-EXPRESSION; BETA-OXIDATION; ADIPOSE-TISSUE; ENERGY-EXPENDITURE; PROFILING REVEALS; GLUCOSE-UPTAKE; LONG;
D O I：
10.1016/j.heliyon.2023.e13316
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Free fatty acids (FFAs) are essential energy sources for most body tissues. A fatty acid must be converted to fatty acyl-CoA to oxidize or be incorporated into new lipids. Acyl-CoA synthetase long-chain family member 5 (ACSL5) is localized in the endoplasmic reticulum and mitochondrial outer membrane, where it catalyzes the formation of fatty acyl-CoAs from long-chain fatty acids (C16-C20). Fatty acyl-CoAs are then used in lipid synthesis or 8-oxidation mediated pathways. ACSL5 plays a pleiotropic role in lipid metabolism depending on substrate preferences, subcel-lular localization and tissue specificity. Here, we review the role of ACSL5 in fatty acid meta-bolism in multiple metabolic tissues, including the liver, small intestine, adipose tissue, and skeletal muscle. Given the increasing number of studies suggesting the role of ACSL5 in glucose and lipid metabolism, we also summarized the effects of ACSL5 on circulating lipids and insulin resistance.
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页数：12
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