The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery

被引:63
作者
di Meo, Nicola Antonio [1 ]
Lasorsa, Francesco [1 ]
Rutigliano, Monica [1 ]
Milella, Martina [1 ]
Ferro, Matteo [2 ]
Battaglia, Michele [1 ]
Ditonno, Pasquale [1 ]
Lucarelli, Giuseppe [1 ,3 ]
机构
[1] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area, Urol Androl & Kidney Transplantat Unit, Bari, Italy
[2] European Inst Oncol, Div Urol, Milan, Italy
[3] Dept Precis & Regenerat Med & Ionian Area, Urol Androl & Kidney Transplantat Unit, Piazza G Cesare 11, I-70124 Bari, Italy
关键词
Biomarker; lipidomics; metabolomics; metabolism; prostate cancer; renal cell carcinoma; FATTY-ACID SYNTHASE; ANDROGEN DEPRIVATION THERAPY; DEUBIQUITINATING ENZYME USP17; DENSITY-LIPOPROTEIN RECEPTOR; CELL CARCINOMA; STATIN USE; POOR-PROGNOSIS; BIOCHEMICAL RECURRENCE; BINDING PROTEIN; CHOLESTEROL-METABOLISM;
D O I
10.1080/14737159.2023.2195553
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
IntroductionLipidomics focuses on the in-depth analysis of lipids, which are crucial macromolecules involved in a wide range of metabolic pathways. The increased intracellular accumulation of different classes of lipids in renal cell carcinoma (RCC) and prostate cancer (PCa) cells may be caused by elevated absorption or by increased de novo lipogenesis as a consequence of lipid metabolism reprogramming. The involvement of cholesterol metabolism in cancer's aberrant pathways has also been demonstrated.Areas coveredThis review provides an update on the most important lipidomics studies and applications in RCC and PCa, with a particular focus on how knowledge of aberrant lipid pathways may be used to identify biomarkers and novel therapeutic targets. In addition, the application of this methodologies have led to novel cancer subtypes identification and patient's risk stratification. Tracking tumor progression using specific biofluid metabolite profiles offers a huge translational opportunity for urological malignancies.Expert opinionLipidomics is a promising branch of 'omics' approach and should include in next decade new standardized analysis methods and randomized clinical trials in order to reach the aim to use this high-throughput technique in patient-tailored therapy perspective.
引用
收藏
页码:297 / 313
页数:17
相关论文
共 203 条
  • [41] HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
    Du, Weinan
    Zhang, Luchang
    Brett-Morris, Adina
    Aguila, Brittany
    Kerner, Janos
    Hoppel, Charles L.
    Puchowicz, Michelle
    Serra, Dolors
    Herrero, Laura
    Rini, Brian I.
    Campbell, Steven
    Welford, Scott M.
    [J]. NATURE COMMUNICATIONS, 2017, 8
  • [42] SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1
    Dulev, Stanimir
    Tkach, Johnny
    Lin, Sichun
    Batada, Nizar N.
    [J]. EMBO REPORTS, 2014, 15 (11) : 1163 - 1174
  • [43] Palmitate-induced Activation of Mitochondrial Metabolism Promotes Oxidative Stress and Apoptosis in H4IIEC3 Rat Hepatocytes
    Egnatchik, Robert A.
    Leamy, Alexandra K.
    Noguchi, Yasushi
    Shiota, Masakazu
    Young, Jamey D.
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2014, 63 (02): : 283 - 295
  • [44] Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma
    Elsherbiny, Marwa E.
    Emara, Marwan
    Godbout, Roseline
    [J]. PROGRESS IN LIPID RESEARCH, 2013, 52 (04) : 562 - 570
  • [45] Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?
    Enciu, Ana-Maria
    Radu, Eugen
    Popescu, Ionela Daniela
    Hinescu, Mihail Eugen
    Ceafalan, Laura Cristina
    [J]. BIOMED RESEARCH INTERNATIONAL, 2018, 2018
  • [46] Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase
    Fang, J
    Feng, Q
    Ketel, CS
    Wang, HB
    Cao, R
    Xia, L
    Erdjument-Bromage, H
    Tempst, P
    Simon, JA
    Zhang, Y
    [J]. CURRENT BIOLOGY, 2002, 12 (13) : 1086 - 1099
  • [47] Association of statin use and oncological outcomes in patients with first diagnosis of T1 high grade non-muscle invasive urothelial bladder cancer: results from a multicenter study
    Ferro, Matteo
    Marchioni, Michele
    Lucarelli, Giuseppe
    Vartolomei, Mihai D.
    Soria, Francesco
    Terracciano, Daniela
    Mistretta, Francesco A.
    Luzzago, Stefano
    Buonerba, Carlo
    Cantiello, Francesco
    Mari, Andrea
    Minervini, Andrea
    Veccia, Alessandro
    Antonelli, Alessandro
    Musi, Gennaro
    Hurle, Rodolfo
    Busetto, Gian M.
    Del Giudice, Francesco
    Chung, Benjamin, I
    Berardinelli, Francesco
    Perdona, Sisto
    Del Prete, Paola
    Mirone, Vincenzo
    Borghesi, Marco
    Porreca, Angelo
    Bove, Pierluigi
    Autorino, Riccardo
    Crisan, Nicolae
    Abu Farhan, Abdal R.
    Battaglia, Michele
    Ditonno, Pasquale
    Russo, Giorgio, I
    Muto, Matteo
    Damiano, Rocco
    Manfredi, Matteo
    Porpiglia, Francesco
    De Cobelli, Ottavio
    Schips, Luigi
    [J]. MINERVA UROLOGY AND NEPHROLOGY, 2021, 73 (06): : 796 - 802
  • [48] Increased Body Mass Index Is a Risk Factor for Poor Clinical Outcomes after Radical Prostatectomy in Men with International Society of Urological Pathology Grade Group 1 Prostate Cancer Diagnosed with Systematic Biopsies
    Ferro, Matteo
    Terracciano, Daniela
    Musi, Gennaro
    de Cobelli, Ottavio
    Vartolomei, Mihai Dorin
    Damiano, Rocco
    Cantiello, Francesco
    Buonerba, Carlo
    Morelli, Michele
    Mistretta, Francesco Alessandro
    Luzzago, Stefano
    Perdona, Sisto
    Del Prete, Paola
    Del Giudice, Francesco
    Busetto, Gian Maria
    Porreca, Angelo
    Autorino, Riccardo
    Manfredi, Matteo
    Porpiglia, Francesco
    Muto, Matteo
    Loizzo, Davide
    Ditonno, Pasquale
    Battaglia, Michele
    Lucarelli, Giuseppe
    [J]. UROLOGIA INTERNATIONALIS, 2022, 106 (01) : 75 - 82
  • [49] An increased body mass index is associated with a worse prognosis in patients administered BCG immunotherapy for T1 bladder cancer
    Ferro, Matteo
    Vartolomei, Mihai Dorin
    Russo, Giorgio Ivan
    Cantiello, Francesco
    Abu Farhan, Abdal Rahman
    Terracciano, Daniela
    Cimmino, Amelia
    Di Stasi, Savino
    Musi, Gennaro
    Hurle, Rodolfo
    Serretta, Vincenzo
    Busetto, Gian Maria
    De Berardinis, Ettore
    Cioffi, Antonio
    Perdona, Sisto
    Borghesi, Marco
    Schiavina, Riccardo
    Cozzi, Gabriele
    Almeida, Gilberto L.
    Bove, Pierluigi
    Lima, Estevao
    Grimaldi, Giovanni
    Matei, Deliu Victor
    Crisan, Nicolae
    Muto, Matteo
    Verze, Paolo
    Battaglia, Michele
    Guazzoni, Giorgio
    Autorino, Riccardo
    Morgia, Giuseppe
    Damiano, Rocco
    de Cobelli, Ottavio
    Shariat, Shahrokh
    Mirone, Vincenzo
    Lucarelli, Giuseppe
    [J]. WORLD JOURNAL OF UROLOGY, 2019, 37 (03) : 507 - 514
  • [50] The emerging role of obesity, diet and lipid metabolism in prostate cancer
    Ferro, Matteo
    Terracciano, Daniela
    Buonerba, Carlo
    Lucarelli, Giuseppe
    Bottero, Danilo
    Perdona, Sisto
    Autorino, Riccardo
    Serino, Alessandro
    Cantiello, Francesco
    Damiano, Rocco
    Andras, Iulia
    De Placido, Sabino
    Di Lorenzo, Giuseppe
    Battaglia, Michele
    Jereczek-Fossa, Barbara A.
    Mirone, Vincenzo
    De Cobelli, Ottavio
    [J]. FUTURE ONCOLOGY, 2017, 13 (03) : 285 - 293