Complications of Deep Brain Stimulation for Parkinson Disease and Relationship between Micro-electrode tracks and hemorrhage: Systematic Review and Meta-Analysis

BACKGROUND: Deep brain stimulation is a common treatment for Parkinson's disease (PD). Despite strong effi-cacy in well-selected patients, complications can occur. Intraoperative micro-electrode recording (MER) can enhance efficacy by improving lead accuracy. However, there is con-troversy as to whether MER increases risk of hemorrhage. -OBJECTIVES: To provide a comprehensive systematic review and meta-analysis reporting complication rates from deep brain stimulation in PD. We also interrogate the association between hemorrhage and MER.METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were implemented while querying the Pubmed, Embase, and Cochrane databases. All included studies were randomized controlled trials and prospective case series with 5 or more patients. Primary outcomes included rates of overall revision, infection, lead malposition, surgical site and wound compli-cations, hardware-related complications, and seizure. The secondary outcome was the relationship between number of MER tracks and hemorrhage rate.RESULTS: 262 articles with 21,261 patients were included in the analysis. Mean follow-up was 25.8 months (range 0e133). Complication rates were: revision 4.9%, infection 4.2%, lead malposition 3.3%, surgical site complications 2.8%, hemorrhage 2.4%, hardware-related complications 2.4%, and seizure 1.9%. While hemorrhage rate did not increase with single-track MER (odds ratio, 3.49; P 1/4 0.29), there was a significant non-linear increase with each additional track.CONCLUSION: Infection and lead malposition were the most common complications. Hemorrhage risk increases with more than one MER track. These results highlight the challenge of balancing surgical accuracy and periopera-tive risk.