Molecular Docking Studies and Application of 6-(1-Arylmethanamino)-2-Phenyl-4H-Chromen-4-Ones as Potent Antibacterial Agents

The present article depicts the synthesis of the series of 6-(1-arylmethanamino)-2-phenyl-4H-chromen-4-ones and their antibacterial activity against the S. aureus. 6-(1-arylmethanamino)-2-phenyl-4H-chromen-4-ones (1a-1n) were obtained via reductive amination reaction of 6-aminoflavone with various commercially available aldehydes. Synthesized compounds and 6-aminoflavone (1) were assessed for their antimicrobial activities against the S. aureus. 6-aminoflavone (1) was found to have an MIC of 2 mu g/mL. The compounds with side chains 4-fluorobenzyl (1a), 4-chlorobenzyl (1b), 4-nitrobenzyl (1e), 4-methoxybenzyl (1g) and (quinolin-2-yl)methyl (1n) were found to have an MIC of 2 mu g/mL. We have demonstrated that 6-(1-arylmethanamino)-2-phenyl-4H-chromen-4-ones are easily accessible via reductive amination reaction. These compounds are found to have antibacterial effect against S. aureus.