Visualization of ferroptosis in brain diseases and ferroptosis-inducing nanomedicine for glioma

被引:0
作者
Wang, Chenyang [1 ,2 ,3 ]
Wen, Li [1 ,2 ,3 ]
Wang, Kun [1 ,2 ,3 ]
Wu, Ruolin [1 ,2 ,3 ]
Li, Mengting [1 ,2 ,3 ]
Zhang, Yajing [1 ,2 ,3 ]
Gao, Zairong [1 ,2 ,3 ]
机构
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Nucl Med, Wuhan 430022, Hubei, Peoples R China
[2] Hubei Key Lab Mol Imaging, Wuhan 430022, Hubei, Peoples R China
[3] Minist Educ, Key Lab Biol Targeted Therapy, Wuhan 430022, Hubei, Peoples R China
来源
AMERICAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2023年 / 13卷 / 05期
基金
中国国家自然科学基金;
关键词
Ferroptosis; molecular imaging; nanomedicine; therapy; glioma; brain diseases; CELL-DEATH; IRON; CANCER; APOPTOSIS;
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
A remarkable body of new data establishes that many degenerative brain diseases and some acute injury situations in the brain may be associated with ferroptosis. In recent years, ferroptosis has also attracted great interest in the cancer research community, partly because it is a unique mode of cell death distinct from other forms and thus has great therapeutic potential for brain cancer. Glioblastoma is a highly aggressive and fatal human cancer, accounting for 60% of all primary brain tumors. Despite the development of various pharmacological and surgical modalities, the survival rates of high-grade gliomas have remained poor over the past few decades. Recent evidence has revealed that ferroptosis is involved in tumor initiation, progression, and metastasis, and manipulating ferroptosis could offer a novel strategy for glioma management. Nanoparticles have been exploited as multifunctional platforms that can cross the blood-brain barrier and deliver therapeutic agents to the brain to address the pressing need for accurate visualization of ferroptosis and glioma treatment. To create efficient and durable ferroptosis inducers, many researchers have engineered nanocomposites to induce a more effective ferroptosis for therapy. In this review, we present the mechanism of ferroptosis and outline the current strategies of imaging and nanotherapy of ferroptosis in brain diseases, especially glioma. We aim to provide up-to-date information on ferroptosis and emphasize the potential clinical implications of ferroptosis for glioma diagnosis and treatment. However, regulation of ferroptosis in vivo remains challenging due to a lack of compounds.
引用
收藏
页码:179 / 194
页数:16
相关论文
共 84 条
  • [1] Elevated Brain Iron in Cocaine Use Disorder as Indexed by Magnetic Field Correlation Imaging
    Adisetiyo, Vitria
    McGill, Corinne E.
    DeVries, William H.
    Jensen, Jens H.
    Hanlon, Colleen A.
    Helpern, Joseph A.
    [J]. BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 2019, 4 (06) : 579 - 588
  • [2] Necroptosis, pyroptosis and apoptosis: an intricate game of cell death
    Bertheloot, Damien
    Latz, Eicke
    Franklin, Bernardo S.
    [J]. CELLULAR & MOLECULAR IMMUNOLOGY, 2021, 18 (05) : 1106 - 1121
  • [3] Recent advances in the molecular understanding of glioblastoma
    Bleeker, Fonnet E.
    Molenaar, Remco J.
    Leenstra, Sieger
    [J]. JOURNAL OF NEURO-ONCOLOGY, 2012, 108 (01) : 11 - 27
  • [4] Iron oxide nanoparticles loaded with paclitaxel inhibits glioblastoma by enhancing autophagy-dependent ferroptosis pathway
    Chen, Hanren
    Wen, Jian
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2022, 921
  • [5] Fluorescence Imaging of Intracellular Glutathione Levels in the Endoplasmic Reticulum to Reveal the Inhibition Effect of Rutin on Ferroptosis
    Chen, Qingxian
    Wang, Yan
    Yue, Tao
    Wei, Hua
    Li, Shijing
    Dong, Baoli
    [J]. ANALYTICAL CHEMISTRY, 2023, 95 (03) : 1949 - 1957
  • [6] Over-expression of lncRNA TMEM161B-AS1 promotes the malignant biological behavior of glioma cells and the resistance to temozolomide via up-regulating the expression of multiple ferroptosis-related genes by sponging hsa-miR-27a-3p
    Chen, Qiudan
    Wang, Weifeng
    Wu, Zhong
    Chen, Shuying
    Chen, Xiaotong
    Zhuang, Shihao
    Song, Guanglei
    Lv, Yuan
    Lin, Yong
    [J]. CELL DEATH DISCOVERY, 2021, 7 (01)
  • [7] Characteristics and Biomarkers of Ferroptosis
    Chen, Xin
    Comish, Paul B.
    Tang, Daolin
    Kang, Rui
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [8] Broadening horizons: the role of ferroptosis in cancer
    Chen, Xin
    Kang, Rui
    Kroemer, Guido
    Tang, Daolin
    [J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2021, 18 (05) : 280 - 296
  • [9] Iron Metabolism in Ferroptosis
    Chen, Xin
    Yu, Chunhua
    Kang, Rui
    Tang, Daolin
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
  • [10] Hyperoxia Induces Ferroptosis and Impairs Lung Development in Neonatal Mice
    Chou, Hsiu-Chu
    Chen, Chung-Ming
    [J]. ANTIOXIDANTS, 2022, 11 (04)