Uric acid-reducing efficacy of Plectranthus amboinicus (Lour.) Spreng in mice with potassium oxonate-induced hyperuricemia

被引：0
作者：
Wang, Chih-Chiang [1 ,2 ]
Chen, Chun [3 ]
Chang, Chih-Wei [4 ,5 ]
Chiu, Po -Yen [4 ,5 ]
Chen, Fu -An [4 ,5 ,6 ,7 ]
机构：
[1] Kaohsiung Armed Forces Gen Hosp, Dept Internal Med, Kaohsiung 802, Taiwan
[2] Natl Def Med Ctr, Sch Med, Taipei 114, Taiwan
[3] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung 807, Taiwan
[4] Tajen Univ, Dept Pharm, Pingtung 907, Taiwan
[5] Tajen Univ, Master Program, Pingtung 907, Taiwan
[6] Tajen Univ, Dept Pharm, 20 Weixin Rd, Pingtung 907, Taiwan
[7] Tajen Univ, Master Program, 20 Weixin Rd, Pingtung 907, Taiwan
来源：
EMIRATES JOURNAL OF FOOD AND AGRICULTURE | 2023年 / 35卷 / 12期
关键词：
Plectranthus amboinicus (Lour.) Spreng; Hyperuricemia; Uric acid-reducing activity; CHRONIC KIDNEY-DISEASE; ALLOPURINOL; GOUT; ASSOCIATION;
D O I：
10.9755/ejfa.2023.3188
中图分类号：
S3 [农学（农艺学）];
学科分类号：
0901 ;
摘要：
Plectranthus amboinicus (Lour.) Spreng is a type of Lamiaceae perennial herb that is widely used in folk treatments for respiratory and skin diseases. Notably, research on the hypouricemic effect of P. amboinicus is limited. This study investigated the uric acid-reducing efficacy of P. amboinicus in mice with potassium oxonate-induced hyperuricemia by performing an in vitro xanthine-oxidase-inhibitionactivity-guided test of P. amboinicus extract (PAE) and its fractions. The ethyl acetate fraction (EAF) of PAE exhibited optimal efficacy in terms of the phenolic content, DPPH scavenging activity, and xanthine oxidase inhibition. We further demonstrated the uric acid-reducing activity of EAF in a mouse model of potassium bromate-induced hyperuricemia. The results can serve as a useful preclinical reference for researching the gout prevention effects of functional foods.
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页码：RESEARCHARTICLE / 1
页数：8
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