Effects of Electrospun Nanofibers on Motor Function Recovery After Spinal Cord Injury: A Systematic Review and Meta-Analysis

被引：0
作者：
Moghaddam, Niloofar Haeri [1 ]
Hashamdar, Somayeh [2 ]
Hamblin, Michael R. [3 ]
Ramezani, Fatemeh [4 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Mens Hlth & Reprod Hlth Res Ctr, Tehran, Iran
[2] Amirkabir Univ Technol, Phys Dept, Tehran, Iran
[3] Univ Johannesburg, Fac Hlth Sci, Laser Res Ctr, Doornfontein, South Africa
[4] Iran Univ Med Sci, Physiol Res Ctr, Tehran, Iran
来源：
WORLD NEUROSURGERY | 2024年 / 181卷
关键词：
-Animal models; -Electrospinning; -Functional recovery; -GFAP; -Neurofilament-200; -Polymeric nanofibers; -Spinal cord injury; MESENCHYMAL STEM-CELLS; III BETA-TUBULIN; LOCAL-DELIVERY; SCAFFOLD; REGENERATION; REGROWTH; HYBRID; FIBERS; REPAIR;
D O I：
10.1016/j.WNEU.2023.10.065
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Nanofibers made by electrospinning have been used as bridging materials in animal models to regenerate nerves after spinal cord injury (SCI). In this metaanalysis study, we investigated the effect of these nanofibers on the motor An extensive search in databases was performed. After primary and secondary screening, data included functional behavior, expression of glial fibrillary acidic protein, neurofilament-200 (NF-200), and b-tubulin III were taken from the articles. The quality control of the articles, statistical analysis, and subgroup analysis were performed. The results from 14 articles and 16 separate experiments showed that electrospun nanofibers used alone could improve motor behavior and reduce glial injury after SCI.
引用
收藏
页码：96 / 106
页数：11
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