The Influence of Polysaccharides on Lipid Metabolism: Insights from Gut Microbiota

被引:12
作者
Huang, Qianqian [1 ]
Zhang, Yanhui [1 ]
Chu, Qiang [2 ]
Song, Haizhao [1 ]
机构
[1] Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Collaborat Innovat Ctr Modern Grain Circulat & Saf, Key Lab Grains & Oils Qual Control & Proc, Nanjing 210023, Peoples R China
[2] Zhejiang Univ, Tea Res Inst, Coll Agr & Biotechnol, Hangzhou 310058, Peoples R China
基金
中国国家自然科学基金;
关键词
gut microbiota; lipid metabolism; mechanism of action; nanocarriers; polysaccharides; HIGH-FAT-DIET; IN-VITRO DIGESTION; BILE-ACID; INTESTINAL MICROBIOTA; GANODERMA-LUCIDUM; BARRIER FUNCTION; IMMUNE-RESPONSE; INDUCED OBESITY; FERMENTATION; INFLAMMATION;
D O I
10.1002/mnfr.202300522
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
ScopePolysaccharides are complex molecules of more than ten monosaccharide residues interconnected through glycosidic linkages formed via condensation reactions. Polysaccharides are widely distributed in various food resources and have gained considerable attention due to their diverse biological activities. This review presented a critical analysis of the existing research literature on anti-obesity polysaccharides and investigates the complex interplay between their lipid-lowering activity and the gut microbiota, aiming to provide a comprehensive overview of the lipid-lowering properties of polysaccharides and the underlying mechanisms of action.Methods and resultsIn this review, the study summarized the roles of polysaccharides in improving lipid metabolism via gut microbiota, including the remodeling of the intestinal barrier, reduction of inflammation, inhibition of pathogenic bacteria, reduction of trimethylamine N-oxide (TMAO) production, and regulation of the metabolism of short-chain fatty acids (SCFAs) and bile acids (BAs).ConclusionThese mechanisms collectively contributed to the beneficial effects of polysaccharides on lipid metabolism and overall metabolic health. Furthermore, polysaccharide-based nanocarriers combined with gut microbiota have broad prospects for developing targeted and personalized therapies for hyperlipidemia and obesity. The lipid-lowering effects of polysaccharides, which are mediated by the gut microbiota, involve a range of mechanisms. These include remodeling of the intestinal barrier, reduction of inflammation, inhibition of pathogenic bacteria, reduction in trimethylamine N-oxide (TMAO) production, and regulation of the metabolism of short-chain fatty acids (SCFAs) and bile acids (BAs).image
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页数:12
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共 94 条
[1]   The gut as the largest endocrine organ in the body [J].
Ahlman, H ;
Nilsson, O .
ANNALS OF ONCOLOGY, 2001, 12 :S63-S68
[2]   Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation [J].
Atarashi, Koji ;
Suda, Wataru ;
Luo, Chengwei ;
Kawaguchi, Takaaki ;
Motoo, Iori ;
Narushima, Seiko ;
Kiguchi, Yuya ;
Yasuma, Keiko ;
Watanabe, Eiichiro ;
Tanoue, Takeshi ;
Thaiss, Christoph A. ;
Sato, Mayuko ;
Toyooka, Kiminori ;
Said, Heba S. ;
Yamagami, Hirokazu ;
Rice, Scott A. ;
Gevers, Dirk ;
Johnson, Ryan C. ;
Segre, Julia A. ;
Chen, Kong ;
Kolls, Jay K. ;
Elinav, Eran ;
Morita, Hidetoshi ;
Xavier, Ramnik J. ;
Hattori, Masahira ;
Honda, Kenya .
SCIENCE, 2017, 358 (6361) :359-+
[3]   Changes seen in gut bacteria content and distribution with obesity: causation or association? [J].
Bell, David S. H. .
POSTGRADUATE MEDICINE, 2015, 127 (08) :863-868
[4]   The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids [J].
Brown, AJ ;
Goldsworthy, SM ;
Barnes, AA ;
Eilert, MM ;
Tcheang, L ;
Daniels, D ;
Muir, AI ;
Wigglesworth, MJ ;
Kinghorn, I ;
Fraser, NJ ;
Pike, NB ;
Strum, JC ;
Steplewski, KM ;
Murdock, PR ;
Holder, JC ;
Marshall, FH ;
Szekeres, PG ;
Wilson, S ;
Ignar, DM ;
Foord, SM ;
Wise, A ;
Dowell, SJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) :11312-11319
[5]   Inflammatory bowel disease and the apical junctional complex [J].
Bruewer, Matthias ;
Samarin, Stanislav ;
Nusrat, Asma .
INFLAMMATORY BOWEL DISEASE: GENETICS, BARRIER FUNCTION, IMMUNOLOGIC MECHANISMS, AND MICROBIAL PATHWAYS, 2006, 1072 :242-252
[6]   Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice [J].
Cani, Patrice D. ;
Bibiloni, Rodrigo ;
Knauf, Claude ;
Neyrinck, Audrey M. ;
Neyrinck, Audrey M. ;
Delzenne, Nathalle M. ;
Burcelin, Remy .
DIABETES, 2008, 57 (06) :1470-1481
[7]  
Cao Y, 2021, FOOD FUNCT, V12, P10121, DOI [10.1039/d1fo02001c, 10.1039/D1FO02001C]
[8]   Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota [J].
Chang, Chih-Jung ;
Lin, Chuan-Sheng ;
Lu, Chia-Chen ;
Martel, Jan ;
Ko, Yun-Fei ;
Ojcius, David M. ;
Tseng, Shun-Fu ;
Wu, Tsung-Ru ;
Chen, Yi-Yuan Margaret ;
Young, John D. ;
Lai, Hsin-Chih .
NATURE COMMUNICATIONS, 2015, 6
[9]   Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease [J].
Chavez-Talavera, Oscar ;
Tailleux, Anne ;
Lefebvre, Philippe ;
Staels, Bart .
GASTROENTEROLOGY, 2017, 152 (07) :1679-+
[10]   Arabinoxylan combined with different glucans improve lipidmetabolism disorder by regulating bile acid and gut microbiota in mice fed with high-fat diet [J].
Chen, Hong ;
Cheng, Jinhua ;
Zhou, Shanshan ;
Chen, Daiwen ;
Qin, Wen ;
Li, Chenglei ;
Li, Hua ;
Lin, Derong ;
Zhang, Qing ;
Liu, Yuntao ;
Liu, Aiping ;
Luo, Yuheng .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 168 :279-288