The Role of Oxytocin in Alzheimer's Disease and Its Relationship with Social Interaction

被引：11
作者：
Takahashi, Junpei [1 ]
Yamada, Daisuke [1 ]
Nagano, Wakana [1 ]
Saitoh, Akiyoshi [1 ]
机构：
[1] Tokyo Univ Sci, Fac Pharmaceut Sci, Lab Pharmacol, 2641 Yamazaki, Noda, Chiba 2788510, Japan
来源：
CELLS | 2023年 / 12卷 / 20期
关键词：
Alzheimer's disease; amyloid beta; dementia; cognitive impairment; learning; memory; social isolation; oxytocin; PARAVENTRICULAR NUCLEUS; SYNAPTIC PLASTICITY; SPATIAL MEMORY; BRAIN; VASOPRESSIN; RECEPTOR; BEHAVIOR; TAU; LONELINESS; ACTIVATION;
D O I：
10.3390/cells12202426
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Alzheimer's disease (AD)-the most common cause of dementia in the elderly-is characterized by progressive memory loss and beta-amyloid protein (A beta) accumulation in the brain. Recently, loneliness was found to be a high risk factor for AD, and social isolation has become a major cause of AD. AD. Oxytocin (OXT), the main hormone involved in social bonding, has been implicated in social interactions, notably in building trust and relationships. Moreover, social isolation or social enrichment modulates the activation of neurons related to OXT. Recently, we reported that OXT reverses learning and memory impairment in AD animal models. Based on the limited number of studies currently available, OXT might be a therapeutic target for AD. Further studies are necessary in order to better understand the role of oxytocin in AD. In this review, we described the relationships between OXT, AD, and social interaction.
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页数：12
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