Hurdles race for CAR T-cell therapy in digestive tract cancer

被引：11

作者：

Kronig, Marie-Noelle ^{[1
]}

Wehrli, Marc ^{[1
,2
,3
]}

Salas-Benito, Diego ^{[2
,3
]}

Maus, Marcela V. ^{[2
,3
]}

机构：

[1] Univ Bern, Dept Med Oncol, Inselspital, Bern Univ Hosp, Bern, Switzerland

[2] Harvard Med Sch, Massachusetts Gen Hosp, Canc Ctr, Boston, MA 02115 USA

[3] Harvard Med Sch, Massachusetts Gen Hosp, Cellular Immunotherapy Program, Canc Ctr, Boston, MA USA

来源：

IMMUNOLOGICAL REVIEWS | 2023年 / 320卷 / 01期

基金：

美国国家卫生研究院;

关键词：

adoptive cell therapy; CAR T cell; clinical trials; digestive tract cancer; METASTATIC COLORECTAL-CANCER; CHIMERIC ANTIGEN RECEPTORS; PHASE-III TRIAL; GASTROESOPHAGEAL JUNCTION; 1ST-LINE TREATMENT; ANTITUMOR-ACTIVITY; PLUS CHEMOTHERAPY; CYTOKINE RELEASE; OPEN-LABEL; NIVOLUMAB;

D O I：

10.1111/imr.13273

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Digestive tract cancers (DTC) belong to the most investigated family of tumors. The incidence, prevalence, and mortality rate of DTC remain high, especially for patients with pancreatic cancer. Even though immunotherapy such as immune checkpoint inhibitors (ICI) have revolutionized the treatment of solid cancer types, ICI are still restricted to a very small group of patients and seem to be more efficacious in combination with chemotherapy. Cellular immunotherapy such as CAR T-cell therapy has entered clinical routine in hematological malignancies with outstanding results. There is growing interest on translating this kind of immunotherapy and success into patients with solid malignancies, such as DTC. This review attempts to describe the major advances in preclinical and clinical research with CAR T cells in DTC, considering the most relevant hurdles in each subtype of DTC.

引用

页码：100 / 119

页数：20

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