Flavonoids: Overview of Biosynthesis, Biological Activity, and Current Extraction Techniques

被引:130
作者
Liga, Sergio [1 ]
Paul, Cristina [1 ]
Peter, Francisc [1 ,2 ]
机构
[1] Politehn Univ Timisoara, Fac Ind Chem & Environm Engn, Dept Appl Chem & Engn Organ & Nat Cpds, Biocatalysis Grp, Carol Telbisz 6, Timisoara 300001, Romania
[2] Politehn Univ Timisoara, Res Inst Renewable Energies, Gavril Muzicescu 138, Timisoara 300501, Romania
来源
PLANTS-BASEL | 2023年 / 12卷 / 14期
关键词
natural compound; bioactive compounds; flavonoids; biological activity; current extraction techniques; ENZYME-ASSISTED EXTRACTION; CANCER; NARINGENIN; METABOLISM; BENEFITS; BIOAVAILABILITY; POLYPHENOLS; INHIBITION; ACTIVATION; CHEMISTRY;
D O I
10.3390/plants12142732
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Recently, increased attention has been paid to natural sources as raw materials for the development of new added-value products. Flavonoids are a large family of polyphenols which include several classes based on their basic structure: flavanones, flavones, isoflavones, flavonols, flavanols, and anthocyanins. They have a multitude of biological properties, such as anti-inflammatory, antioxidant, antiviral, antimicrobial, anticancer, cardioprotective, and neuroprotective effects. Current trends of research and development on flavonoids relate to identification, extraction, isolation, physico-chemical characterization, and their applications to health benefits. This review presents an up-to-date survey of the most recent developments in the natural flavonoid classes, the biological activity of representative flavonoids, current extraction techniques, and perspectives.
引用
收藏
页数:25
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共 156 条
[1]  
Abhari K, 2020, ADV FOOD NUTR RES, V92, P35, DOI 10.1016/bs.afnr.2019.12.004
[2]   Naringenin inhibits prostate cancer metastasis by blocking voltage-gated sodium channels [J].
Aktas, Hatice Gumushan ;
Akgun, Tuba .
BIOMEDICINE & PHARMACOTHERAPY, 2018, 106 :770-775
[3]   Dietary Flavanols: A Review of Select Effects on Vascular Function, Blood Pressure, and Exercise Performance [J].
Al-Dashti, Yousef A. ;
Holt, Roberta R. ;
Stebbins, Charles L. ;
Keen, Carl L. ;
Hackman, Robert M. .
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2018, 37 (07) :553-567
[4]   Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer [J].
AL-Ishaq, Raghad Khalid ;
Liskova, Alena ;
Kubatka, Peter ;
Busselberg, Dietrich .
CANCERS, 2021, 13 (16)
[5]   Therapeutic Potential of Isoflavones with an Emphasis on Daidzein [J].
Alshehri, Mohammed M. ;
Sharifi-Rad, Javad ;
Herrera-Bravo, Jesus ;
Jara, Evelyn L. ;
Salazar, Luis A. ;
Kregiel, Dorota ;
Uprety, Yadav ;
Akram, Muhammad ;
Iqbal, Mehwish ;
Martorell, Miquel ;
Torrens-Mas, Margalida ;
Pons, Daniel Gabriel ;
Dastan, Sevgi Durna ;
Cruz-Martins, Natalia ;
Ozdemir, Fethi Ahmet ;
Kumar, Manoj ;
Cho, William C. .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021, 2021
[6]   Optimization of enzyme-assisted extraction of anthocyanins from eggplant (Solanum melongena L.) peel [J].
Amulya, PR. ;
ul Islam, Rayees .
FOOD CHEMISTRY-X, 2023, 18
[7]   Impact of Dietary Flavanols on Microbiota, Immunity and Inflammation in Metabolic Diseases [J].
Angeles Martin, Maria ;
Ramos, Sonia .
NUTRIENTS, 2021, 13 (03) :1-24
[8]   Impact of cocoa flavanols on human health [J].
Angeles Martin, Maria ;
Ramos, Sonia .
FOOD AND CHEMICAL TOXICOLOGY, 2021, 151
[9]   Simultaneous extraction with two phases (modified supercritical CO2 and CO2-expanded liquid) to enhance sustainable extraction/isolation of pinocembrin from Lippia origanoides (Verbenaceae) [J].
Arias, Julian ;
Munoz, Felix ;
Mejia, Jesica ;
Kumar, Arvind ;
Villa, Aida Luz ;
Martinez, Jairo Rene ;
Stashenko, Elena E. .
ADVANCES IN SAMPLE PREPARATION, 2023, 6
[10]   Optimization of flavonoids extraction from Lippia graveolens and Lippia origanoides chemotypes with ethanol-modified supercritical CO2 after steam distillation [J].
Arias, Julian ;
Mejia, Jesica ;
Cordoba, Yuri ;
Martinez, Jairo Rene ;
Stashenko, Elena ;
del Valle, Jose Manuel .
INDUSTRIAL CROPS AND PRODUCTS, 2020, 146