Synthesis and Biological Evaluation of Simplified Ansellone Analogues with Lipophilic Side Chains as HIV Latency-Reversing Agents

被引：1
|
作者：
Yanagihara, Mizushi [1 ]
Kishimoto, Naoki [2 ]
Nakahara, Kanae [1 ]
Abe, Towa [2 ]
Miura, Satoshi [2 ]
Lin, Bangzhong [1 ]
Fumimoto, Megumi [1 ]
Haruta, Junichi [1 ]
Misumi, Shogo [2 ]
Arisawa, Mitsuhiro [1 ]
Murai, Kenichi [1 ]
机构：
[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan
[2] Kumamoto Univ, Fac Med & Pharmaceut Sci, Dept Environm & Mol Hlth Sci, Kumamoto 8620973, Japan
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2023年 / 29卷 / 44期
基金：
日本学术振兴会;
关键词：
ansellone; HIV latency-reversing agents; medicinal chemistry; natural products; oxygen heterocycles; PROTEIN-KINASE-C; NATURAL-PRODUCTS; INHIBITOR; DRUGS;
D O I：
10.1002/chem.202300677
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Structurally simplified analogues of ansellone A, in which the decalin skeleton is replaced with a lipophilic chain, were prepared and their HIV latency-reversing activities biologically evaluated. In particular, two analogues bearing ether and alkenyl side chains, respectively, showed comparable activities to that of ansellone A. Each of the simplified compounds was easily synthesized using Prins cyclisation chemistry.
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收藏
页数：7
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